IN October 1902, a “peculiar anomaly in human red blood corpuscles... came to notice in the
histologic laboratory of the Ohio State University,” Columbus, Ohio.“Examination disclosed …

With increased recognition of the profound morbidity of sickle cell disease and with growing
evidence of the efficacy of transfusion therapy in prevention and treatment of sickle cell …

BACKGROUND: Most sickle cell anemia patients undergo transfusion therapy to prevent
complications. The Stroke Prevention Trial in Sickle Cell Anemia showed that transfusion …

Background: Development of alloantibodies against the foreign red blood cell (RBC)(
alloimmunization) is a well-known complication in thalassemia patients when performing …

BACKGROUND: Because of intensive marrow depression and improved survival, patients
with hematologic and oncologic malignancies are dependent on transfusion for a longer …

BACKGROUND: Red blood cell (RBC) alloimmunization is common in transfused patients.
Most studies report on the rate of alloimmunization in chronically transfused patients, which …

Background: The development of anti-red blood cell antibodies (both allo-and
autoantibodies) remains a major problem in thalassemia major patients. We studied the …

Factors regulating which patients become alloimmunized to red blood cell (RBC) antigens
are poorly understood. Using a murine model of transfusion, we recently reported that viral …

Sickle cell disease (SCD) is the most common hereditary hemoglobinopathy. The underlying
pathophysiology of the red blood cell (RBC) leads to pan-systemic complications which …

Background Alloimmunization remains a significant complication of transfusion and has
been associated with multiple factors, including inflammation, an important pathophysiologic …