Alnustone: a review of its sources, pharmacology, and pharmacokinetics

Z Salari, M Alavi, H Rezaii-Zadeh… - Current Molecular …, 2024 - benthamdirect.com
Alnustone (4 (E)-, 6 (E)-1, 7-Diphenyl-hepta-4, 6-dien-3-one) is a non-phenolic natural
diarylheptanoid, which was first isolated and identified from the male flower of Alnus …

Alnustone inhibits the growth of hepatocellular carcinoma via ROS‐mediated PI3K/Akt/mTOR/p70S6K axis

L Wang, L Cheng, L Ma, A Ahmad Farooqi… - Phytotherapy …, 2022 - Wiley Online Library
Alnustone, a diarylheptane compound, exhibits potent growth inhibition against
hepatocellular carcinoma (HCC) BEL‐7402 cells. However, the underlying mechanisms …

Human Estrogen Receptor Alpha Antagonists, Part 3: 3-D Pharmacophore and 3-D QSAR Guided Brefeldin A Hit-to-Lead Optimization toward New Breast Cancer …

N Kurtanović, N Tomašević, S Matić, E Proia… - Molecules, 2022 - mdpi.com
The estrogen receptor α (ERα) is an important biological target mediating 17β-estradiol
driven breast cancer (BC) development. Aiming to develop innovative drugs against BC …

A natural inhibitor of diapophytoene desaturase attenuates methicillin‐resistant Staphylococcus aureus (MRSA) pathogenicity and overcomes drug‐resistance

B Han, H Wang, X Niu - British Journal of Pharmacology, 2024 - Wiley Online Library
Abstract Background and Purpose At present, the inhibition of staphyloxanthin biosynthesis
has emerged as a prominent strategy in combating methicillin‐resistant Staphylococcus …

A new diarylheptanoid from Alpinia officinarum promotes the differentiation of 3T3-L1 preadipocytes

X Zhang, X Zhang, Y Wang, F Chen, Y Li… - Natural Product …, 2018 - Taylor & Francis
A new diarylheptanoid, namely trans-(4 R, 5 S)-epoxy-1, 7-diphenyl-3-heptanone (1), and a
new natural product, 7-(4 ″-hydroxy-3 ″-methoxyphenyl)-1-phenyl-hepta-4 E, 6 E-dien-3 …

Pharmacokinetics and tissue distribution of Alnustone in rats after intravenous administration by liquid chromatography-mass spectrometry

Y Song, Y Zhou, XT Yan, JB Bi, X Qiu, Y Bian, KF Wang… - Molecules, 2019 - mdpi.com
Alnustone, a nonphenolic diarylheptanoid, first isolated from Alnus pendula (Betulaceae),
has recently received a great deal of attention due to its various beneficial pharmacological …

Synthesis of alnustone-like diarylpentanoids via a 4+ 1 strategy and assessment of their potential anticancer activity

N Çelebioğlu, ÖÖ Tozlu, H Türkez… - Turkish Journal of …, 2023 - journals.tubitak.gov.tr
Abstract Twelve compounds with a 1, 5-diaryl-1-penten-3-one structure were synthesized
and their cytotoxic activities were evaluated. The 1, 5-diaryl-1-penten-3-one compounds …

PREDIKSI TOKSISITAS SENYAWA JAMU ANTI-HIPERTENSI DENGAN RESEPTOR ANGIOTENSIN II TIPE 1 (AGTR1) SECARA IN SILICO

R Lestari, LA Setiani, U Suhendar - Majalah Farmasi dan …, 2023 - journal.unhas.ac.id
Penggunaan jamu antihipertensi dimasyarakat merupakan salah satu pengobatan
hipertensi. Kombinasi tanaman sebagai antihipertensi terdiri dari Imperatae rhizoma …

Syntheses and antibacterial activities of 4 linear nonphenolic diarylheptanoids

ŞB Demİr, H Secinti, N ÇelebİoĞlu… - Turkish Journal of …, 2020 - journals.tubitak.gov.tr
Four linear nonphenolic diarylheptanoids were synthesized and their antibacterial activities
were studied.($ S) $-2-Me-CBS-catalysed reduction of alnustone with BH $ _ {3} $. SMe …

Two efficient methods for the total synthesis of the natural diarylheptanoid 7-(4-hydroxyphenyl)-1-phenylheptan-3-one

E Gurel, T Kaya, N Celebioglu… - Organic …, 2024 - avesis.atauni.edu.tr
Diarylheptanoids are compounds with an ArC7Ar structure, where two aromatic rings are
connected by a seven-carbon chain. To date, over 500 structurally diverse diarylheptanoids …