Zinc signals and immunity

M Maywald, I Wessels, L Rink - International journal of molecular sciences, 2017 - mdpi.com
Zinc homeostasis is crucial for an adequate function of the immune system. Zinc deficiency
as well as zinc excess result in severe disturbances in immune cell numbers and activities …

[HTML][HTML] The molecular basis of mammary gland development and epithelial differentiation

PF Slepicka, AVH Somasundara… - Seminars in cell & …, 2021 - Elsevier
Our understanding of the molecular events underpinning the development of mammalian
organ systems has been increasing rapidly in recent years. With the advent of new and …

Biological underpinnings of breastfeeding challenges: the role of genetics, diet, and environment on lactation physiology

S Lee, SL Kelleher - American Journal of Physiology …, 2016 - journals.physiology.org
Lactation is a dynamic process that has evolved to produce a complex biological fluid that
provides nutritive and nonnutritive factors to the nursing offspring. It has long been assumed …

ROS and intracellular ion channels

K Kiselyov, S Muallem - Cell Calcium, 2016 - Elsevier
Oxidative stress is a well-known driver of numerous pathological processes involving protein
and lipid peroxidation and DNA damage. The resulting increase of pro-apoptotic pressure …

[HTML][HTML] Molecular mechanism of mammary gland involution: An update

MK Jena, S Jaswal, S Kumar, AK Mohanty - Developmental biology, 2019 - Elsevier
The mammary gland (MG) is a unique organ responsible for milk synthesis, secretion, and
involution to prepare the gland for subsequent lactation. The mammary epithelial cells …

How cellular Zn2+ signaling drives physiological functions

N Levaot, M Hershfinkel - Cell Calcium, 2018 - Elsevier
Zinc is an essential micronutrient affecting many aspects of human health. Cellular Zn 2+
homeostasis is critical for cell function and survival. Zn 2+, acting as a first or second …

Breast cancers co-opt normal mechanisms of tolerance to promote immune evasion and metastasis

LS Crump, KT Kines, JK Richer… - American Journal of …, 2022 - journals.physiology.org
Normal developmental processes, such as those seen during embryonic development and
postpartum mammary gland involution, can be reactivated by cancer cells to promote …

The role of lysosome in cell death regulation

F Yu, Z Chen, B Wang, Z Jin, Y Hou, S Ma, X Liu - Tumor Biology, 2016 - Springer
Lysosome is a highly membrane-bound organelle which possesses a sequence of
biological functions including protein degradation, cell signal transduction, plasma …

Virulence‐associated protein A from Rhodococcus equi is an intercompartmental pH‐neutralising virulence factor

K Von Bargen, M Scraba, I Krämer… - Cellular …, 2019 - Wiley Online Library
Professional phagocytic cells such as macrophages are a central part of innate immune
defence. They ingest microorganisms into membrane‐bound compartments (phagosomes) …

ZnT2 is an electroneutral proton-coupled vesicular antiporter displaying an apparent stoichiometry of two protons per zinc ion

Y Golan, R Alhadeff, A Warshel… - PLOS Computational …, 2019 - journals.plos.org
Zinc is a vital trace element crucial for the proper function of some 3,000 cellular proteins.
Specifically, zinc is essential for key physiological processes including nucleic acid …