The development of dialysis by early pioneers such as Willem Kolff and Belding Scribner set
in motion several dramatic changes in the epidemiology, economics and ethical frameworks …

Background Gut microbial metabolites have been implicated as novel risk factors for
cardiovascular events and premature death. The strength and consistency of associations …

Given the high risk of infection-related mortality, patients with end-stage kidney disease
(ESKD) may be at increased risk with COVID-19. To assess this, we compared outcomes of …

Significant disparities in CKD rates and outcomes exist between black and white Americans.
Health disparities are defined as health differences that adversely affect disadvantaged …

The field of organ transplantation benefits from large, comprehensive, transplant-specific
national data sets available to researchers. In addition to the widely used Organ …

Background In the context of clinical research, investigators have historically selected the
outcomes that they consider to be important, but these are often discordant with patients' …

Background: Poor physical performance and frailty are associated with elevated risks of
death and disability. Chronic kidney disease (CKD) is also strongly associated with these …

Cardiovascular disease causes over 50% of the deaths in dialysis patients, and the risk of
death is higher in white than in black patients. The underlying mechanisms for these findings …

Importance Most children with end-stage kidney disease (ESKD) are treated with dialysis
prior to transplant. It is not known whether their outcomes have changed in recent years …

Importance The Affordable Care Act Medicaid expansion may be associated with reduced
mortality, but evidence to date is limited. Patients with end-stage renal disease (ESRD) are a …