A genome-to-genome analysis of associations between human genetic variation, HIV-1 sequence diversity, and viral control
HIV-1 sequence diversity is affected by selection pressures arising from host genomic
factors. Using paired human and viral data from 1071 individuals, we ran> 3000 genome …
factors. Using paired human and viral data from 1071 individuals, we ran> 3000 genome …
Impact of pre-adapted HIV transmission
Human leukocyte antigen class I (HLA)-restricted CD8+ T lymphocyte (CTL) responses are
crucial to HIV-1 control. Although HIV can evade these responses, the longer-term impact of …
crucial to HIV-1 control. Although HIV can evade these responses, the longer-term impact of …
Correlates of protective cellular immunity revealed by analysis of population-level immune escape pathways in HIV-1
ABSTRACT HLA class I-associated polymorphisms identified at the population level mark
viral sites under immune pressure by individual HLA alleles. As such, analysis of their …
viral sites under immune pressure by individual HLA alleles. As such, analysis of their …
HIV escape mutations occur preferentially at HLA-binding sites of CD8 T-cell epitopes
C Bronke, CAM Almeida, E McKinnon, SG Roberts… - Aids, 2013 - journals.lww.com
Objective: To define the relative frequencies of different mechanisms of viral escape. Design:
A population-based approach to examine the distribution of HIV polymorphism associated …
A population-based approach to examine the distribution of HIV polymorphism associated …
High frequency of HIV mutations associated with HLA-c suggests enhanced HLA-c–restricted CTL selective pressure associated with an AIDS-protective …
ME Blais, Y Zhang, T Rostron, H Griffin… - The Journal of …, 2012 - journals.aai.org
Delayed HIV-1 disease progression is associated with a single nucleotide polymorphism
upstream of the HLA-C gene that correlates with differential expression of the HLA-C Ag …
upstream of the HLA-C gene that correlates with differential expression of the HLA-C Ag …
Positioning of APOBEC3G/F Mutational Hotspots in the Human Immunodeficiency Virus Genome Favors Reduced Recognition by CD8+ T Cells
M Monajemi, CF Woodworth, K Zipperlen, M Gallant… - PLoS …, 2014 - journals.plos.org
Due to constitutive expression in cells targeted by human immunodeficiency virus (HIV), and
immediate mode of viral restriction upon HIV entry into the host cell, APOBEC3G (A3G) and …
immediate mode of viral restriction upon HIV entry into the host cell, APOBEC3G (A3G) and …
Nef-specific CD8+ T cell responses contribute to HIV-1 immune control
E Adland, JM Carlson, P Paioni, H Kløverpris… - PloS one, 2013 - journals.plos.org
Recent studies in the SIV-macaque model of HIV infection suggest that Nef-specific CD8+ T-
cell responses may mediate highly effective immune control of viraemia. In HIV infection Nef …
cell responses may mediate highly effective immune control of viraemia. In HIV infection Nef …
Deep sequence analysis of HIV adaptation following vertical transmission reveals the impact of immune pressure on the evolution of HIV
Human immunodeficiency virus (HIV) can adapt to an individual's T cell immune response
via genomic mutations that affect antigen recognition and impact disease outcome. These …
via genomic mutations that affect antigen recognition and impact disease outcome. These …
Viremic control and viral coreceptor usage in two HIV-1-infected persons homozygous for CCR5 Δ32
TJ Henrich, E Hanhauser, Z Hu, HJ Stellbrink, C Noah… - Aids, 2015 - journals.lww.com
Objectives: To determine viral and immune factors involved in transmission and control of
HIV-1 infection in persons without functional CCR5. Design: Understanding transmission …
HIV-1 infection in persons without functional CCR5. Design: Understanding transmission …
HLA class-II associated HIV polymorphisms predict escape from CD4+ T cell responses
N Erdmann, VY Du, J Carlson, M Schaefer… - PLoS …, 2015 - journals.plos.org
Antiretroviral therapy, antibody and CD8+ T cell-mediated responses targeting human
immunodeficiency virus-1 (HIV-1) exert selection pressure on the virus necessitating …
immunodeficiency virus-1 (HIV-1) exert selection pressure on the virus necessitating …