The reactions of organic azides and alkynes catalysed by copper species represent the
prototypical examples of click chemistry. The so-called CuAAC reaction (copper-catalysed …

The selective chemical modification of biological molecules drives a good portion of modern
drug development and fundamental biological research. While a few early examples of …

In the past 15 years, there have been rapid developments in the ability to cotranslationally
incorporate unnatural amino acids into proteins produced in cells, both at defined sites via …

The copper‐catalyzed azide/alkyne cycloaddition reaction (CuAAC) has emerged as the
most useful “click” chemistry. Polymer science has profited enormously from CuAAC by its …

Over the past 15 years a great deal of progress has been made on the discovery,
rediscovery, and invention of bioorthogonal reactions between functional groups that do not …

This review is focused on the mechanistic aspects and recent trends of the metal-catalyzed
azide-alkyne cycloaddition (MAAC) so-called “click” reactions with catalysts based on …

Bioorthogonal chemistries can be used to tag diverse classes of biomolecules in cells and
other complex environments. With over 20 unique transformations now available, though …

The use of covalent chemistry to track biomolecules in their native environment—a focus of
bioorthogonal chemistry—has received considerable interest recently among chemical …

We report that azides capable of copper-chelation undergo much faster “Click chemistry”(
copperaccelerated azide-alkyne cycloaddition, or CuAAC) than nonchelating azides under a …

The emergence of bioorthogonal reactions has greatly broadened the scope of biomolecule
labeling and detecting. Of all the bioorthogonal reactions that have been developed, the …