Tumors are among the leading causes of death worldwide. Cell-derived biomimetic
functional materials have shown great promise in the treatment of tumors. These materials …

Background: Blood transfusion is a life-saving intervention for millions of recipients
worldwide. Over the last 15 years, the advent of high-throughput, affordable omics …

Red blood cell (RBC) deformability, expressing their ability to change their shape, allows
them to minimize their resistance to flow and optimize oxygen delivery to the tissues. RBC …

Eukaryotic cells are defined as cells containing distinct nuclei and other membranous
organelles. However, red blood cells (RBCs) lack a nucleus and organelles—perhaps to …

β-thalassemia and sickle cell disease (SCD) are inherited hemoglobinopathies that result in
both quantitative and qualitative variations in the β-globin chain. These in turn lead to …

Red blood cells (RBCs) release hemoglobin (Hb)-containing extracellular vesicles (EVs)
throughout their lifespan in the circulation, and especially during senescence, by spleen …

Prestorage filtration of blood to remove contaminating donor leukocytes and platelets has
substantially increased the safety level of transfusion therapy. We have previously shown …

Blood donors with beta-thalassemia traits (βThal+) have proven to be good “storers”, since
their stored RBCs are resistant to lysis and resilient against oxidative/proteotoxic stress. To …

Piezo1 is a mechanosensitive ion channel required for various biological processes, but its
regulation remains poorly understood. Here, we used erythrocytes to address this question …

Transfusion of packed red blood cell (RBCs) saves millions of lives yearly worldwide,
making packed RBCs the most commonly administered drug in hospitals after vaccines …