Infiltration of macrophages in solid tumours is associated with poor prognosis and correlates
with chemotherapy resistance in most cancers. In mouse models of cancer, macrophages …

Diabetic retinopathy is a common complication of diabetes and remains the leading cause of
blindness among the working-age population. For decades, diabetic retinopathy was …

In the past few decades, biological drugs and small molecule inhibitors targeting
inflammatory cytokines, immune cells, and intracellular kinases have become the standard …

The term ferroptosis was put forward in 2012 and has been researched exponentially over
the past few years. Ferroptosis is an unconventional pattern of iron-dependent programmed …

In the past decade, advances in the use of monoclonal antibodies (mAbs) and adoptive
cellular therapy to treat cancer by modulating the immune response have led to …

CD40 is a cell-surface member of the TNF (tumor necrosis factor) receptor superfamily.
Upon activation, CD40 can license dendritic cells to promote antitumor T cell activation and …

Platelets are anucleate cytoplasmic fragments derived from the fragmentation of medullary
megakaryocytes. Activated platelets adhere to the damaged endothelium by means of …

Cancer is one of the most deadly diseases in the modern world. The last decade has
witnessed dramatic advances in cancer treatment through immunotherapy. One extremely …

Therapeutic targeting of immune checkpoints has garnered significant attention in the area
of cancer immunotherapy, in which efforts have focused in particular on cytotoxic T …

CD40 is a TNF receptor superfamily member expressed on both immune and non-immune
cells. Interactions between B cell-expressed CD40 and its binding partner, CD40L …