Adipocyte Regulation of Insulin Sensitivity and the Risk of Type 2 Diabetes | New England Journal
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Diabetes, a silent killer, is one of the most widely prevalent conditions of the present time.
According to the 2017 International Diabetes Federation (IDF) statistics, the global …

NAFLD is closely linked with hepatic insulin resistance. Accumulation of hepatic
diacylglycerol activates PKC-ε, impairing insulin receptor activation and insulin-stimulated …

Insulin resistance is associated with numerous metabolic disorders, such as obesity and
type II diabetes, that currently plague our society. Although insulin normally promotes …

Although ample evidence links hepatic lipid accumulation with hepatic insulin resistance,
the mechanistic basis of this association is incompletely understood and controversial …

There is general agreement that the acute suppression of hepatic glucose production by
insulin is mediated by both a direct and an indirect effect on the liver. There is, however, no …

Lipotoxicity is characterized by the ectopic accumulation of lipids in organs different from
adipose tissue. Lipotoxicity is mainly associated with dysfunctional signaling and insulin …

Background Peroxisomes are single membrane-bound organelles named for their role in
hydrogen peroxide production and catabolism. However, their cellular functions extend well …

Basal insulin continues to be a vital part of therapy for many people with diabetes. First
attempts to prolong the duration of insulin formulations were through the development of …

The brain has been traditionally thought to be insensitive to insulin, primarily because
insulin does not stimulate glucose uptake/metabolism in the brain (as it does in classic …