Over the past few years it has become evident that the intermediate filament proteins, the
types A and B nuclear lamins, not only provide a structural framework for the nucleus, but …

The nuclear lamins are type V intermediate filament proteins that are critically important for
the structural properties of the nucleus. In addition, they are involved in the regulation of …

Many nuclear proteins form lamin-dependent complexes, including LEM-domain proteins,
nesprins and SUN-domain proteins. These complexes have roles in chromatin organization …

The nuclear envelope is often depicted as a static barrier that regulates access between the
nucleus and the cytosol. However, recent research has identified many conditions in …

Mutations in genes encoding the intermediate filament nuclear lamins and associated
proteins cause a wide spectrum of diseases sometimes called “laminopathies.” Diseases …

Emery–Dreifuss muscular dystrophy (EDMD) is a heterogeneous late-onset disease
involving skeletal muscle wasting and heart defects caused, in a minority of cases, by …

It has been demonstrated that nuclear lamins are important proteins in maintaining cellular
as well as nuclear integrity, and in maintaining chromatin organization in the nucleus …

Intermediate filaments provide scaffolding for the cell and protect it against stress. This
comprehensive review points out that there are more than 100 intermediate filament genes …

The nuclear lamina provides structural support to the nucleus and has a central role in
nuclear organization and gene regulation. Defects in its constituents, the lamins, lead to a …

Intermediate filament (IF) proteins and heat shock proteins (HSPs) are large multimember
families that share several features, including protein abundance, significant upregulation in …