Enhanced radiation sensitivity in HPV-positive head and neck cancer

RJ Kimple, MA Smith, GC Blitzer, AD Torres, JA Martin… - Cancer research, 2013 - AACR
Patients with human papillomavirus (HPV+)–associated head and neck cancer (HNC) show
significantly improved survival outcome compared with those with HPV-negative (HPV−) …

HPV-induced oropharyngeal cancer, immune response and response to therapy

HL Vu, AG Sikora, S Fu, J Kao - Cancer letters, 2010 - Elsevier
Approximately 25% of head and neck squamous cell carcinoma (HNSCC) worldwide are
associated with high-risk human papillomaviruses (HPV). HPV-positive HNSCCs have a …

Biological basis for increased sensitivity to radiation therapy in HPV‐positive head and neck cancers

V Bol, V Grégoire - BioMed research international, 2014 - Wiley Online Library
Although development of head and neck squamous cell carcinomas (HNSCCs) is commonly
linked to the consumption of tobacco and alcohol, a link between human papillomavirus …

Impact of multiple HPV infection on response to treatment and survival in patients receiving radical radiotherapy for cervical cancer

B Bachtiary, A Obermair, B Dreier… - … journal of cancer, 2002 - Wiley Online Library
To obtain information on the incidence and the clinical significance of infection with various
types of the human papillomavirus (HPV) in cancer of the uterine cervix, we retrospectively …

Human papillomavirus DNA load and p16INK4a expression predict for local control in patients with anal squamous cell carcinoma treated with chemoradiotherapy

F Rödel, U Wieland, I Fraunholz, J Kitz… - … journal of cancer, 2015 - Wiley Online Library
As the detection rate of HPV‐DNA in anal carcinoma commonly exceeds 90%, a comparison
between sole HPV‐positive and HPV‐negative cancers with respect to treatment response …

Downregulation of SMG-1 in HPV-positive head and neck squamous cell carcinoma due to promoter hypermethylation correlates with improved survival

E Gubanova, B Brown, SV Ivanov, T Helleday… - Clinical cancer …, 2012 - AACR
Purpose: Human papillomavirus (HPV) is linked with a subset of head and neck squamous
cell carcinomas (HNSCC). HPV-positive HNSCCs show a better prognosis than HPV …

Investigation of radiosensitivity gene signatures in cancer cell lines

JS Hall, R Iype, J Senra, J Taylor, L Armenoult… - PloS one, 2014 - journals.plos.org
Intrinsic radiosensitivity is an important factor underlying radiotherapy response, but there is
no method for its routine assessment in human tumours. Gene signatures are currently …

Decreased local immune response and retained HPV gene expression during chemoradiotherapy are associated with treatment resistance and death from cervical …

PF Cosper, C McNair, I González… - … journal of cancer, 2020 - Wiley Online Library
More than one‐third of patients with locally advanced cervical cancer do not respond to
chemoradiation therapy (CRT). We aimed to characterize the transcriptional landscape of …

Mechanistic signatures of human papillomavirus insertions in anal squamous cell carcinomas

A Morel, C Neuzillet, M Wack, S Lameiras, S Vacher… - Cancers, 2019 - mdpi.com
The role of human papillomavirus (HPV) in anal squamous cell carcinoma (ASCC)
carcinogenesis has been clearly established, involving the expression of viral oncoproteins …

Radiosensitization of oropharyngeal squamous cell carcinoma cells by human papillomavirus 16 oncoprotein E6∗ I

E Pang, NC Delic, A Hong, M Zhang, BR Rose… - International Journal of …, 2011 - Elsevier
PURPOSE: Patients with oropharyngeal squamous cell carcinoma (OSCC) whose disease
is associated with high-risk human papillomavirus (HPV) infection have a significantly better …