Abstract CD4+ T helper (Th) cells are critical for proper immune cell homeostasis and host
defense, but are also major contributors to pathology of autoimmune and inflammatory …

Myelin basic protein (MBP) is an abundant protein in central nervous system (CNS) myelin.
MBP has long been studied as a factor in the pathogenesis of the autoimmune …

Experimental autoimmune encephalomyelitis (EAE) is the most commonly used
experimental model for the human inflammatory demyelinating disease, multiple sclerosis …

Since the discovery of interleukin-10 (IL-10) in the 1980s, a large body of work has led to its
recognition as a pleiotropic immunomodulatory cytokine that affects both the innate and …

Background Although macrophages (MΦ) are known as essential players in wound healing,
their contribution to recovery from spinal cord injury (SCI) is a subject of debate. The …

Clonal composition and T cell receptor (TCR) repertoire of CD4+ and CD8+ T cells
infiltrating actively demyelinating multiple sclerosis (MS) lesions were determined with …

Eighty percent of individuals with multiple sclerosis (MS) initially develop a clinical pattern
with periodic relapses followed by remissions, called relapsing-remitting MS (RRMS). This …

Multiple sclerosis (MS) is the most common autoimmune of MBP encoded in the Golli–MBP
gene (Pribyl et al., disease involving the nervous system. In the United 1993) are actually …

Multiple sclerosis (MS) is a commonly occurring inflammatory and demyelinating
neurological disease. It has been considered to be an autoimmune disorder mediated by …

Monocyte chemoattractant protein (MCP)-1 plays a critical role in innate immunity by
directing the migration of monocytes into inflammatory sites. Recent data indicated a …