Parkinson's disease (PD) is a neurodegenerative disorder with symptoms that progressively
worsen with age. Pathologically, PD is characterized by the aggregation of α-synuclein in …

The toxicity of misfolded proteins and mitochondrial dysfunction are pivotal factors that
promote age-associated functional neuronal decline and neurodegenerative disease …

Aging is associated with cognitive decline and increasing risk of neurodegeneration.
Perturbation of mitochondrial function, dynamics, and trafficking are implicated in the …

Numerous conserved signaling pathways play critical roles in aging, including insulin/IGF-1,
TGF-β, and Wnt pathways. Some of these pathways also play prominent roles in the …

Ultraviolet radiations (UV) are the primary causative agent for skin aging (photoaging) and
cancer, especially UV-A. The mode of action and the molecular mechanism behind the …

The molecular basis of Parkinson's disease (PD) is currently unknown. There is increasing
evidence that fat metabolism is at the crossroad of key molecular pathways associated with …

Many nutritional interventions that increase lifespan are also proposed to postpone age-
related declines in motor and cognitive function. Potential sources of anti-aging compounds …

Neurons receive excitatory or sensory inputs through their dendrites, which often branch
extensively to form unique neuron-specific structures. How neurons regulate the formation of …

Medicinal berries are appreciated for their health benefits, in traditional ecological
knowledge and nutrition science. Determining the cellular mechanisms underlying the …

Understanding cellular outcomes, such as neuronal remodeling, that are common to both
healthy and diseased aging brains is essential to the development of successful brain aging …