Most deaths from breast cancer result from tumor recurrence, but mechanisms underlying
tumor relapse are largely unknown. We now report that Par-4 is downregulated during tumor …

The origin of cancer remains one of the most important enigmas in modern biology. This
paper presents a hypothesis for the origin of carcinomas in which cellular aging and …

Abstract Background/Aim: Prostate apoptosis response 4 (PAR4), a tumour-suppressor
protein, selectively induces apoptosis of cancer cells without affecting normal cells. Its …

Most deaths from breast cancer result from tumour recurrence, which is typically an
incurable disease. Down-regulation of the pro-apoptotic tumour suppressor protein prostate …

One of the greatest challenges of cancer therapeutics nowadays is to find selective targets
successfully. Prostate apoptosis response-4 (Par-4) is a selective tumor suppressor protein …

Introduction: Apoptosis plays an important role in age-related disease, and prostate
apoptosis response-4 (PAR-4) is a novel apoptosis-inducing factor that regulates apoptosis …

Docetaxel is an effective drug for the treatment of metastatic breast cancer. However, the
exact mechanisms and/or markers associated with chemosensitivity or resistance to …

Background Anticancer genes are an endogenous defense against transformed cells as
they impose antineoplastic effects upon ectopic expression. Profiling the expression of these …

Background: Prostate apoptosis response-4 (PAR4) plays an important role in apoptosis
and survival of cancer cells. The current study aimed to further elucidate its role in breast …

Background We evaluated five key proteins involved in various cancer-related pathways
and assessed their relation to breast cancer recurrence. Methods We used the Kentucky …