Highlights•Voltage-gated ion channels participate in memory formation.•Intrinsic plasticity is
not only global but it might be also local.•Intrinsic plasticity shares common learning rules …

Studies on synaptic plasticity in the context of learning have been dominated by the view
that a single, particular type of plasticity forms the underlying mechanism for a particular type …

The cerebellar cortex is an important system for relating neural circuits and learning. Its
promise reflects the longstanding idea that it contains simple, repeated circuit modules with …

Small-conductance Ca2+-activated K+ channels (SK channels) are widely expressed
throughout the central nervous system. These channels are activated solely by increases in …

Synaptic plasticity (eg, long-term potentiation [LTP]) is considered the cellular correlate of
learning. Recent optogenetic studies on memory engram formation assign a critical role in …

Neurons are generally considered to communicate information by increasing or decreasing
their firing rate. However, in principle, they could in addition convey messages by using …

Loss-of-function mutations in the gene encoding the postsynaptic scaffolding protein
SHANK2 are a highly penetrant cause of autism spectrum disorders (ASD) involving …

Cerebellar dysfunction relates to various psychiatric disorders, including autism spectrum
and depressive disorders. However, the physiological aspect is less advanced. Here, we …

Cerebellar granule cells (GCs) account for more than half of all neurons in the CNS of
vertebrates. Theoretical work has suggested that the abundance of GCs is advantageous for …

A puzzling observation in the study of autism spectrum disorder (ASD) in mouse models has
been the deregulation of long-term synaptic depression (LTD), a form of experience …