Optogenetics for light control of biological systems

V Emiliani, E Entcheva, R Hedrich… - Nature Reviews …, 2022 - nature.com
Optogenetic techniques have been developed to allow control over the activity of selected
cells within a highly heterogeneous tissue, using a combination of genetic engineering and …

Towards translational optogenetics

A Bansal, S Shikha, Y Zhang - Nature Biomedical Engineering, 2023 - nature.com
Optogenetics is widely used to interrogate the neural circuits underlying disease and has
most recently been harnessed for therapeutic applications. The optogenetic toolkit consists …

Micro‐light emitting diode: from chips to applications

PJ Parbrook, B Corbett, J Han… - Laser & Photonics …, 2021 - Wiley Online Library
Typical light‐emitting diodes (LEDs) have a form factor>(300× 300) µm2. Such LEDs are
commercially mature in illumination and ultralarge displays. However, recent LED research …

Neural recording and modulation technologies

R Chen, A Canales, P Anikeeva - Nature Reviews Materials, 2017 - nature.com
In the mammalian nervous system, billions of neurons connected by quadrillions of
synapses exchange electrical, chemical and mechanical signals. Disruptions to this network …

Systemic AAV vectors for widespread and targeted gene delivery in rodents

RC Challis, S Ravindra Kumar, KY Chan, C Challis… - Nature protocols, 2019 - nature.com
We recently developed adeno-associated virus (AAV) capsids to facilitate efficient and
noninvasive gene transfer to the central and peripheral nervous systems. However, a …

Electrospinning: An enabling nanotechnology platform for drug delivery and regenerative medicine

S Chen, R Li, X Li, J Xie - Advanced drug delivery reviews, 2018 - Elsevier
Electrospinning provides an enabling nanotechnology platform for generating a rich variety
of novel structured materials in many biomedical applications including drug delivery …

Cardiac optogenetics: a decade of enlightenment

E Entcheva, MW Kay - Nature Reviews Cardiology, 2021 - nature.com
The electromechanical function of the heart involves complex, coordinated activity over time
and space. Life-threatening cardiac arrhythmias arise from asynchrony in these space–time …

Porosity-based heterojunctions enable leadless optoelectronic modulation of tissues

A Prominski, J Shi, P Li, J Yue, Y Lin, J Park, B Tian… - Nature Materials, 2022 - nature.com
Homo-and heterojunctions play essential roles in semiconductor-based devices such as
field-effect transistors, solar cells, photodetectors and light-emitting diodes. Semiconductor …

Wireless, battery-free, fully implantable multimodal and multisite pacemakers for applications in small animal models

P Gutruf, RT Yin, KB Lee, J Ausra, JA Brennan… - Nature …, 2019 - nature.com
Small animals support a wide range of pathological phenotypes and genotypes as versatile,
affordable models for pathogenesis of cardiovascular diseases and for exploration of …

ReaChR: a red-shifted variant of channelrhodopsin enables deep transcranial optogenetic excitation

JY Lin, PM Knutsen, A Muller, D Kleinfeld… - Nature …, 2013 - nature.com
Channelrhodopsins (ChRs) are used to optogenetically depolarize neurons. We engineered
a variant of ChR, denoted red-activatable ChR (ReaChR), that is optimally excited with …