Optogenetics for light control of biological systems
Optogenetic techniques have been developed to allow control over the activity of selected
cells within a highly heterogeneous tissue, using a combination of genetic engineering and …
cells within a highly heterogeneous tissue, using a combination of genetic engineering and …
Towards translational optogenetics
Optogenetics is widely used to interrogate the neural circuits underlying disease and has
most recently been harnessed for therapeutic applications. The optogenetic toolkit consists …
most recently been harnessed for therapeutic applications. The optogenetic toolkit consists …
Micro‐light emitting diode: from chips to applications
Typical light‐emitting diodes (LEDs) have a form factor>(300× 300) µm2. Such LEDs are
commercially mature in illumination and ultralarge displays. However, recent LED research …
commercially mature in illumination and ultralarge displays. However, recent LED research …
Neural recording and modulation technologies
In the mammalian nervous system, billions of neurons connected by quadrillions of
synapses exchange electrical, chemical and mechanical signals. Disruptions to this network …
synapses exchange electrical, chemical and mechanical signals. Disruptions to this network …
Systemic AAV vectors for widespread and targeted gene delivery in rodents
RC Challis, S Ravindra Kumar, KY Chan, C Challis… - Nature protocols, 2019 - nature.com
We recently developed adeno-associated virus (AAV) capsids to facilitate efficient and
noninvasive gene transfer to the central and peripheral nervous systems. However, a …
noninvasive gene transfer to the central and peripheral nervous systems. However, a …
Electrospinning: An enabling nanotechnology platform for drug delivery and regenerative medicine
Electrospinning provides an enabling nanotechnology platform for generating a rich variety
of novel structured materials in many biomedical applications including drug delivery …
of novel structured materials in many biomedical applications including drug delivery …
Cardiac optogenetics: a decade of enlightenment
E Entcheva, MW Kay - Nature Reviews Cardiology, 2021 - nature.com
The electromechanical function of the heart involves complex, coordinated activity over time
and space. Life-threatening cardiac arrhythmias arise from asynchrony in these space–time …
and space. Life-threatening cardiac arrhythmias arise from asynchrony in these space–time …
Porosity-based heterojunctions enable leadless optoelectronic modulation of tissues
Homo-and heterojunctions play essential roles in semiconductor-based devices such as
field-effect transistors, solar cells, photodetectors and light-emitting diodes. Semiconductor …
field-effect transistors, solar cells, photodetectors and light-emitting diodes. Semiconductor …
Wireless, battery-free, fully implantable multimodal and multisite pacemakers for applications in small animal models
Small animals support a wide range of pathological phenotypes and genotypes as versatile,
affordable models for pathogenesis of cardiovascular diseases and for exploration of …
affordable models for pathogenesis of cardiovascular diseases and for exploration of …
ReaChR: a red-shifted variant of channelrhodopsin enables deep transcranial optogenetic excitation
JY Lin, PM Knutsen, A Muller, D Kleinfeld… - Nature …, 2013 - nature.com
Channelrhodopsins (ChRs) are used to optogenetically depolarize neurons. We engineered
a variant of ChR, denoted red-activatable ChR (ReaChR), that is optimally excited with …
a variant of ChR, denoted red-activatable ChR (ReaChR), that is optimally excited with …