[HTML][HTML] Traditional Chinese medicine for coronary artery disease treatment: clinical evidence from randomized controlled trials

B Liang, N Gu - Frontiers in cardiovascular medicine, 2021 - frontiersin.org
Traditional Chinese medicine has a history of more than 2,000 years and has been widely
used in clinical practice. However, due to the lack of a reliable scientific basis, the role of …

Innovative strategy in treating angina pectoris with Chinese patent medicines by promoting blood circulation and removing blood stasis: experience from combination …

XJ Xiong, Z Wang, J Wang - Current Vascular Pharmacology, 2015 - ingentaconnect.com
Coronary heart disease (CHD) is one of the leading causes of death worldwide. Moreover,
angina pectoris is one of the most important types of CHD. Therefore, prevention and …

The therapeutical effect of Chinese medicine for the treatment of atherosclerotic coronary heart disease

J Zhang, H Meng, Y Zhang, X Zhang… - Current …, 2017 - ingentaconnect.com
Coronary heart disease (CHD) is the leading cause of mortality in the world and
atherosclerosis is the main cause of CHD. Traditional Chinese medicines have been …

Neuroprotective effects of Tongxinluo on focal cerebral ischemia and reperfusion injury in rats associated with the activation of the MEK1/2/ERK1/2/p90RSK signaling …

Z Yu, M Cai, X Li, J Zhang, T Wu, F Yang, W Zhu… - Brain Research, 2018 - Elsevier
Ischemic stroke brings a huge family and social burden. Although the reperfusion of
ischemic cerebral tissue is the most important way to rescue ischemic stroke, ischemia …

[HTML][HTML] Clinical effects and mechanisms of a Chinese patent medicine, Tongxinluo capsule, as an adjuvant treatment in coronary heart disease

J Wang, TL Li, PF Chang, YQ Gao, JS Fan, CH Zhang… - Heliyon, 2024 - cell.com
Coronary heart disease (CHD) is the leading cause of death globally, posing a serious
threat to human health. However, the current treatment approaches available for CHD fall …

The efficacy of Chinese herbal drugs for adults with angina pectoris: Bayesian network meta-analysis of 331 RCTs involving 36,467 individuals

Y Jia, S Leung - Journal of Ethnopharmacology, 2024 - Elsevier
Ethnopharmacological relevance Hundreds of randomized controlled trials (RCT) on
Chinese herbal drugs (CHDs) including Shexiang baoxin pill (BXP), compound Danshen …

Macrophages aggravate hypoxia-induced cardiac microvascular endothelial cell injury via peroxynitrite: protection by tongxinluo

X Wang, K Liu, B Li, Y Li, K Ye, J Qi… - Cell communication & …, 2015 - Taylor & Francis
Activated macrophages contribute to endothelial dysfunction; however, it is unclear how
peroxynitrite contributes to macrophage-mediated human cardiac microvascular endothelial …

Tongxinluo inhibits cyclooxygenase-2, inducible nitric oxide synthase, hypoxia-inducible factor-2α/vascular endothelial growth factor to antagonize injury in hypoxia …

YN Li, XJ Wang, B Li, K Liu, JS Qi, BH Liu… - Chinese Medical …, 2015 - mednexus.org
Background: Endothelial dysfunction is considered as the initiating process and pathological
basis of cardiovascular disease. Cyclooxygenase-2 (COX-2) and prostacyclin synthase …

High glucose decreases claudins-5 and-11 in cardiac microvascular endothelial cells: Antagonistic effects of tongxinluo

B Li, Y Li, K Liu, X Wang, J Qi, B Wang… - Endocrine …, 2017 - Taylor & Francis
Purpose/aim of the study: Claudins-5,-9, and-11 are tight-junction proteins that are mainly
expressed in endothelial cells. Their deficiency may lead to cell barrier dysfunction, which is …

[HTML][HTML] Efficacy and safety of tongxinluo capsule for angina pectoris of coronary heart disease: an overview of systematic reviews and meta-analysis

L Li, P Feng, W Zhou, B Luo, L Deng, D Gan… - Frontiers in …, 2024 - frontiersin.org
Background Tongxinluo capsule (TXLC) is a common drug for treating angina pectoris of
coronary heart disease (CHD). In recent years, many systematic reviews (SRs) and meta …