Once deemed heretical, emerging evidence now supports the notion that the inheritance of
acquired characteristics can occur through ancestral exposures or experiences and that …

Like protein and DNA, different types of RNA molecules undergo various modifications.
Accumulating evidence suggests that these RNA modifications serve as sophisticated codes …

Background Nanopore long-read sequencing technology greatly expands the capacity of
long-range, single-molecule DNA-modification detection. A growing number of analytical …

To enable low-cost, high-throughput generation of cistrome and epicistrome maps for any
organism, we developed DNA affinity purification sequencing (DAP-seq), a transcription …

The definition of epigenetics refers that molecular modifications on DNA that can regulate
gene activity are independent of DNA sequence and mitotically stable. Notably, epigenetics …

Estrogen receptor alpha (ERα) has been recognized now for several decades as playing a
key role in reproduction and exerting functions in numerous nonreproductive tissues. In this …

Abstract N 6-Methyladenosine (m6A) is a widespread, reversible chemical modification of
RNA molecules, implicated in many aspects of RNA metabolism. Little quantitative …

2-Oxoglutarate (2OG)-dependent oxygenases (2OGXs) catalyze a remarkably diverse range
of oxidative reactions. In animals, these comprise hydroxylations and N-demethylations …

Reactive oxygen species (ROS) have emerged as important cellular-signaling agents for
cellular survival. Herein, we demonstrate that ROS-mediated oxidation of DNA to yield 8-oxo …

Recent advances in understanding different RNAs and unique features of their biology have
revealed a wealth of information. However, approaches to identify small molecules that …