The reorganization of metabolic pathways in cancer facilitates the flux of carbon and
reducing equivalents into anabolic pathways at the expense of oxidative phosphorylation …

Over the last several decades, significant technical and experimental advances have made
quantitative nuclear magnetic resonance (qNMR) a valuable analytical tool for quantitative …

Mutations in the gene isocitrate dehydrogenase 1 (IDH1) are present in up to 86% of grade II
and III gliomas and secondary glioblastoma. Arginine 132 (R132) mutations in the enzyme …

Summary HLA class I (HLA-I) glycoproteins drive immune responses by presenting antigens
to cognate CD8+ T cells. This process is often hijacked by tumors and pathogens for …

Specific neurochemicals measured with proton magnetic resonance spectroscopy (1H-
MRS) may serve as biomarkers of pathological mechanism in the brain. We used high field …

This article focuses on the description of some of the NMR techniques used in the field of
biomedical and pharmaceutical research. Indeed, the NMR method has special …

Glioblastomas (GBMs), the most frequent and aggressive human primary brain tumours,
have altered cell metabolism, and one of the strongest indicators of malignancy is an …

Simple Summary This review discusses the synthesis and significance of fatty acids,
glycerophospholipids, and triacylglycerol in glioblastoma. The focus is on all enzymes …

Background Mutations in isocitrate dehydrogenase (IDH) 1 have been reported in over 70%
of low-grade gliomas and secondary glioblastomas. IDH1 is the enzyme that catalyzes the …

Many patients with glioma harbor specific mutations in the isocitrate dehydrogenase gene
IDH1 that associate with a relatively better prognosis. IDH1-mutated tumors produce the …