The mitochondrial permeability transition (mPT) describes a Ca2+-dependent and
cyclophilin D (CypD)-facilitated increase of inner mitochondrial membrane permeability that …

Major progress has been made in defining the basis of the mitochondrial permeability
transition, a Ca2+‐dependent permeability increase of the inner membrane that has puzzled …

The ageing process is a systemic decline from cellular dysfunction to organ degeneration,
with more predisposition to deteriorated disorders. Rejuvenation refers to giving aged cells …

Cardiac aging is evident by a reduction in function which subsequently contributes to heart
failure. The metabolic microenvironment has been identified as a hallmark of malignancy …

Aging and age-related neurodegeneration are both associated with the accumulation of
unfolded and abnormally folded proteins, highlighting the importance of protein homeostasis …

It is widely reported that the mitochondrial membrane potential,∆ Ψm, is reduced in aging
animals. It was recently suggested that the lower∆ Ψm in aged animals modulates …

Mitochondrial dysfunction is a key hub that is common to many diseases. Mitochondria's role
in energy production, calcium homeostasis, and ROS balance makes them essential for cell …

Abstract The mitochondrial Permeability Transition Pore (PTP) can be defined as a Ca 2+
activated mega-channel involved in mitochondrial damage and cell death, making its …

We review the findings that establish that perturbations of various aspects of mitochondrial
function, including oxidative phosphorylation, can promote lifespan extension, with different …

The mitochondrial unfolded protein response (UPRmt) and mitophagy are two mitochondrial
quality control (MQC) systems that work at the molecular and organelle levels, respectively …