A recent paper in this journal sought to counter evidence for the role of transport proteins in
effecting drug uptake into cells, and questions that transporters can recognize drug …

Introduction: Computational methods have been widely applied to toxicology across
pharmaceutical, consumer product and environmental fields over the past decade. Progress …

Drug-induced blockade of the human ether-à-go-go-related gene (hERG) channel is today
considered the main cause of cardiotoxicity in postmarketing surveillance. Hence, several …

Capsule networks (CapsNets), a new class of deep neural network architectures proposed
recently by Hinton et al., have shown a great performance in many fields, particularly in …

Gain-of-function (GoF) variants in KCNT1 channels cause severe, drug-resistant forms of
epilepsy. Quinidine is a known KCNT1 blocker, but its clinical use is limited due to severe …

The lipophilic polycyclic aromatic hydrocarbon (PAH) phenanthrene is relatively abundant in
polluted air and water and can access and accumulate in human tissue. Phenanthrene has …

The human ether-a-go-go-related gene (hERG) not only encodes a potassium-selective
voltage-gated ion channel essential for normal electrical activity in the heart but is also a …

The goal of this study was to design, experimentally validate, and apply a virtual screening
workflow to identify novel hERG channel blockers. The hERG channel is an important …

Modulation of the human Ether-à-go-go-Related Gene (hERG) channel, a crucial voltage-
gated potassium channel in the repolarization of action potentials in ventricular myocytes of …

The human ether-a-go-go-related gene (hERG) potassium channel is a well-known
contributor to drug-induced cardiotoxicity and therefore is an extremely important target …