G protein–coupled receptors (GPCRs) are the largest family of cell surface receptors. Class
B1 GPCRs constitute a subfamily of 15 receptors that characteristically contain large …

G protein-coupled receptors are important drug targets that engage and activate signaling
transducers in multiple cellular compartments. Delineating therapeutic signaling from …

Pituitary Adenylate Cyclase-Activating Peptide (PACAP) and Vasoactive Intestinal Peptide
(VIP) are neuropeptides involved in a diverse array of physiological and pathological …

Tirzepatide (LY3298176) is a fatty-acid-modified, dual incretin receptor agonist that exhibits
pharmacology similar to native GIP at the glucose-dependent insulinotropic polypeptide …

Glucagon-like peptide-1 receptor (GLP-1R) and glucagon receptor (GCGR), two members of
class B1 G protein–coupled receptors, play important roles in glucose homeostasis and …

The activation of G protein-coupled receptors (GPCRs) is triggered by ligand binding to their
orthosteric sites, which induces ligand-specific conformational changes. Agonists and …

The glucagon-like peptide-1 receptor (GLP-1R) is a key regulator of blood glucose and a
prime target for the treatment of type II diabetes and obesity with multiple public drugs. Here …

Recent advances in G-protein-coupled receptor (GPCR) structural elucidation have
strengthened previous hypotheses that multidimensional signal propagation mediated by …

Cagrilintide is a novel long-acting amylin receptor agonist, which has shown a potent
induction of weight loss. Interestingly, cagrilintide is a Dual Amylin and Calcitonin Receptor …

We have applied an underexplored backbone modification strategy to generate new
analogues of peptides that activate two clinically important class B1 G protein-coupled …