In the last decades, the number of patients receiving chemotherapy has considerably
increased. Given the toxicity of cytotoxic agents to humans (not only for patients but also for …

Objectives: Antineoplastic drugs are known reproductive and developmental toxicants. Our
objective was to review the existing literature of reproductive health risks to workers who …

Purpose Significant advances in the awareness of safe handling of HDs have been made
since the previous version of these guidelines was published in 2006. NIOSH has created a …

The toxicity of antineoplastic drugs has been well known since they were introduced in the
1940s. Because most antineoplastic drugs are nonselective in their mechanism of action …

Objective: This study evaluated health care worker exposure to antineoplastic drugs.
Methods: A cross-sectional study examined environmental samples from pharmacy and …

Purpose. Surface contamination with the antineoplastic drugs cyclophosphamide,
ifosfamide, and 5-fluorouracil was compared in 22 US hospital pharmacies following …

Surface contamination with and personnel exposure to antineoplastic agents before and
after the implementation of a closed-system protective device were studied. Samples were …

Objective: To determine the frequency of “signature” chromosomal abnormalities in
oncology workers handling anticancer drugs. Methods: Peripheral blood from health care …

Purpose. The results of three studies that describe the external contamination of
chemotherapy drug vials are presented. New techniques for the improved decontamination …

The majority of anticancer agents has in common DNA-damaging properties and affects not
only target-cells but also non-tumour cells. Its genotoxicity has been demonstrated in …