A hallmark of retroviral replication is establishment of the proviral state, wherein a DNA copy
of the viral RNA genome is stably incorporated into a host cell chromosome. Integrase is the …

Transposable elements and retroviruses are found in most genomes, can be pathogenic
and are widely used as gene-delivery and functional genomics tools. Exploring whether …

Lentiviruses can infect non-dividing cells, and various cellular transport proteins provide
crucial functions for lentiviral nuclear entry and integration. We previously showed that the …

A hallmark of retroviral replication is integration of the viral genome into host cell DNA. This
characteristic makes retrovirus-based vectors attractive delivery vehicles for gene therapy …

A two-step, high-throughput RNAi silencing screen was used to identify host cell factors
required during human papillomavirus type 16 (HPV16) infection. Analysis of validated hits …

Retroviruses integrate their reverse transcribed genomes into host cell chromosomes as an
obligate step in virus replication. The nuclear envelope separates the chromosomes from …

Retroviral replication proceeds through an obligate integrated DNA provirus, making
retroviral vectors attractive vehicles for human gene-therapy. Though most of the host cell …

Integration is central to HIV-1 replication and helps mold the reservoir of cells that persists in
AIDS patients. HIV-1 interacts with specific cellular factors to target integration to interior …

Replication-defective retroviral vectors have been used for more than 25 years as a tool for
efficient and stable insertion of therapeutic transgenes in human cells. Patients suffering …

Here, we review genomic target site selection during retroviral integration as a multistep
process in which specific biases are introduced at each level. The first asymmetries are …