Serotonin 5-HT6 Receptor Antagonists in Alzheimer's Disease: Therapeutic Rationale and Current Development Status
Alzheimer's disease (AD) is the most common cause of dementia in elderly people. Because
of the lack of effective treatments for this illness, research focused on identifying compounds …
of the lack of effective treatments for this illness, research focused on identifying compounds …
Ellagic Acid, Kaempferol, and Quercetin from Acacia nilotica: Promising Combined Drug With Multiple Mechanisms of Action
MY Al-Nour, MM Ibrahim, T Elsaman - Current pharmacology reports, 2019 - Springer
The pharmacological activity of Acacia nilotica's phytochemical constituents was confirmed
with evidence-based studies, but the determination of exact targets that they bind and the …
with evidence-based studies, but the determination of exact targets that they bind and the …
Anticancer Drug Discovery based on Natural products: from computational approaches to Clinical studies
Globally, malignancies cause one out of six mortalities, which is a serious health problem.
Cancer therapy has always been challenging, apart from major advances in …
Cancer therapy has always been challenging, apart from major advances in …
Identification of NS2B-NS3 protease inhibitors for therapeutic application in ZIKV infection: A pharmacophore-based high-throughput virtual screening and MD …
Zika virus (ZIKV) pandemic and its implication in congenital malformations and severe
neurological disorders had created serious threats to global health. ZIKV is a mosquito …
neurological disorders had created serious threats to global health. ZIKV is a mosquito …
Has molecular docking ever brought us a medicine
MA Phillips, MA Stewart, DL Woodling… - Molecular docking, 2018 - books.google.com
Molecular docking has been developed and improving for many years, but its ability to bring
a medicine to the drug market effectively is still generally questioned. In this chapter, we …
a medicine to the drug market effectively is still generally questioned. In this chapter, we …
A structural view on medicinal chemistry strategies against drug resistance
The natural phenomenon of drug resistance is a widespread issue that hampers the
performance of drugs in many major clinical indications. Antibacterial and antifungal drugs …
performance of drugs in many major clinical indications. Antibacterial and antifungal drugs …
Advances in drug discovery based on genomics, proteomics and bioinformatics in malaria
S Aggarwal, A Karmakar… - Current Topics in …, 2023 - ingentaconnect.com
Malaria is one of the neglected infectious diseases, and drugs are the first line of action
taken against the onset of malaria as therapeutics. The drugs can be of either natural or …
taken against the onset of malaria as therapeutics. The drugs can be of either natural or …
Recent advances in quantitative structure–activity relationship models of antimalarial drugs
Introduction Due to emerging resistance to the first-line artemisinin-based antimalarials and
lack of efficient vaccines and limited chemotherapeutic alternatives, there is an urgent need …
lack of efficient vaccines and limited chemotherapeutic alternatives, there is an urgent need …
Structure-and ligand-based drug design methods for the modeling of antimalarial agents: a review of updates from 2012 onwards
VK Vyas, S Bhati, S Patel, M Ghate - Journal of Biomolecular …, 2022 - Taylor & Francis
Malaria still persists as one of the deadliest infectious disease having a huge morbidity and
mortality affecting the higher population of the world. Structure and ligand-based drug …
mortality affecting the higher population of the world. Structure and ligand-based drug …
Convolutional neural network-based quantitative structure–activity relationship and fingerprint analysis against inhibitors of anthrax lethal factor
M Kumari, N Subbarao - Future Medicinal Chemistry, 2023 - Taylor & Francis
Aim: To develop a one-dimensional convolutional neural network-based quantitative
structure–activity relationship (1D-CNN-QSAR) model to identify novel anthrax inhibitors and …
structure–activity relationship (1D-CNN-QSAR) model to identify novel anthrax inhibitors and …