Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy
M Chehelgerdi, F Behdarvand Dehkordi… - Molecular Cancer, 2023 - Springer
The advent of iPSCs has brought about a significant transformation in stem cell research,
opening up promising avenues for advancing cancer treatment. The formation of cancer is a …
opening up promising avenues for advancing cancer treatment. The formation of cancer is a …
[HTML][HTML] Unravelling glioblastoma heterogeneity by means of single-cell RNA sequencing
AH Martínez, R Madurga, N García-Romero… - Cancer letters, 2022 - Elsevier
Glioblastoma (GBM) is the most invasive and deadliest brain cancer in adults. Its inherent
heterogeneity has been designated as the main cause of treatment failure. Thus, a deeper …
heterogeneity has been designated as the main cause of treatment failure. Thus, a deeper …
Differentiation of the tumor microenvironment: are CAFs the Organizer?
M Kochetkova, MS Samuel - Trends in cell biology, 2022 - cell.com
Cancers contain a suite of genetically stable cells within an extracellular matrix, collectively
termed the tumor microenvironment (TME). The TME strongly influences disease outcome …
termed the tumor microenvironment (TME). The TME strongly influences disease outcome …
Interactions between anti-angiogenic therapy and immunotherapy in glioblastoma
Glioblastoma is the most aggressive brain tumor with a median survival ranging from 6.2 to
16.7 months. The complex interactions between the tumor and the cells of tumor …
16.7 months. The complex interactions between the tumor and the cells of tumor …
The tumor microenvironment of medulloblastoma: an intricate multicellular network with therapeutic potential
NFHN van Bree, M Wilhelm - Cancers, 2022 - mdpi.com
Simple Summary The current treatment options for medulloblastoma, the most common
malignant childhood brain cancer, are associated with many negative side effects and …
malignant childhood brain cancer, are associated with many negative side effects and …
Integrative multi-omics approach to targeted therapy for glioblastoma
L Koh, W Novera, SW Lim, YK Chong, QY Pang… - Pharmacological …, 2022 - Elsevier
This review describes recent technological advances applied to glioblastoma (GBM), a brain
tumor with dismal prognosis. International consortial efforts suggest the presence of …
tumor with dismal prognosis. International consortial efforts suggest the presence of …
Deciphering Glioblastoma: Fundamental and Novel Insights into the Biology and Therapeutic Strategies of Gliomas
R Onciul, FM Brehar, C Toader… - Current Issues in …, 2024 - mdpi.com
Gliomas constitute a diverse and complex array of tumors within the central nervous system
(CNS), characterized by a wide range of prognostic outcomes and responses to therapeutic …
(CNS), characterized by a wide range of prognostic outcomes and responses to therapeutic …
Non-Tumor Cells within the Tumor Microenvironment—The “Eminence Grise” of the Glioblastoma Pathogenesis and Potential Targets for Therapy
AS Bugakova, DA Chudakova, MS Myzina… - Cells, 2024 - mdpi.com
Glioblastoma (GBM) is the most common malignancy of the central nervous system in adults.
GBM has high levels of therapy failure and its prognosis is usually dismal. The phenotypic …
GBM has high levels of therapy failure and its prognosis is usually dismal. The phenotypic …
[HTML][HTML] Pan-cancer transcriptomic analysis of CNS tumor stroma identifies a population of perivascular fibroblasts that predict poor immunotherapy response in …
M Zarodniuk, A Steele, X Lu, J Li, M Datta - Research Square, 2023 - ncbi.nlm.nih.gov
Excessive deposition of extracellular matrix (ECM) is a hallmark of solid tumors; however, it
remains poorly understood which cellular and molecular components contribute to the …
remains poorly understood which cellular and molecular components contribute to the …