Engineered human blood–brain barrier microfluidic model for vascular permeability analyses
The blood–brain barrier (BBB) greatly restricts the entry of biological and engineered
therapeutic molecules into the brain. Due to challenges in translating results from animal …
therapeutic molecules into the brain. Due to challenges in translating results from animal …
Development of polymeric nanoparticles for blood–brain barrier transfer—strategies and challenges
Neurological disorders such as Alzheimer's disease, stroke, and brain cancers are difficult to
treat with current drugs as their delivery efficacy to the brain is severely hampered by the …
treat with current drugs as their delivery efficacy to the brain is severely hampered by the …
3D self-organized microvascular model of the human blood-brain barrier with endothelial cells, pericytes and astrocytes
The blood-brain barrier (BBB) regulates molecular trafficking, protects against pathogens,
and prevents efficient drug delivery to the brain. Models to date failed to reproduce the …
and prevents efficient drug delivery to the brain. Models to date failed to reproduce the …
Microengineered human blood–brain barrier platform for understanding nanoparticle transport mechanisms
Challenges in drug development of neurological diseases remain mainly ascribed to the
blood–brain barrier (BBB). Despite the valuable contribution of animal models to drug …
blood–brain barrier (BBB). Despite the valuable contribution of animal models to drug …
Advances in Hydrogels in Organoids and Organs‐on‐a‐Chip
Significant advances in materials, microscale technology, and stem cell biology have
enabled the construction of 3D tissues and organs, which will ultimately lead to more …
enabled the construction of 3D tissues and organs, which will ultimately lead to more …
Biology and models of the blood–brain barrier
The blood–brain barrier (BBB) is one of the most selective endothelial barriers. An
understanding of its cellular, morphological, and biological properties in health and disease …
understanding of its cellular, morphological, and biological properties in health and disease …
Interconnected microphysiological systems for quantitative biology and pharmacology studies
Microphysiological systems (MPSs) are in vitro models that capture facets of in vivo organ
function through use of specialized culture microenvironments, including 3D matrices and …
function through use of specialized culture microenvironments, including 3D matrices and …
Tissue engineering and regenerative medicine: achievements, future, and sustainability in Asia
F Han, J Wang, L Ding, Y Hu, W Li, Z Yuan… - … in bioengineering and …, 2020 - frontiersin.org
Exploring innovative solutions to improve the healthcare of the aging and diseased
population continues to be a global challenge. Among a number of strategies toward this …
population continues to be a global challenge. Among a number of strategies toward this …
A perfused human blood–brain barrier on-a-chip for high-throughput assessment of barrier function and antibody transport
NR Wevers, DG Kasi, T Gray, KJ Wilschut… - Fluids and Barriers of …, 2018 - Springer
Background Receptor-mediated transcytosis is one of the major routes for drug delivery of
large molecules into the brain. The aim of this study was to develop a novel model of the …
large molecules into the brain. The aim of this study was to develop a novel model of the …
High-throughput methods in the discovery and study of biomaterials and materiobiology
The complex interaction of cells with biomaterials (ie, materiobiology) plays an increasingly
pivotal role in the development of novel implants, biomedical devices, and tissue …
pivotal role in the development of novel implants, biomedical devices, and tissue …