Our wellness relies on continuous interactions between our brain and body: different organs
relay their current state to the brain and are regulated, in turn, by descending visceromotor …

Variation in an animal's behavioral state is linked to fluctuations in brain activity and
cognitive ability. In the neocortex, state-dependent circuit dynamics may reflect …

Vagus nerve stimulation (VNS) is a neuromodulation therapy for a broad and expanding set
of neurologic conditions. However, the mechanism through which VNS influences central …

Short-term memory deficits have been associated with prefrontal cortex (PFC) dysfunction in
Alzheimer's disease (AD) and AD mouse models. Extratelencephalic projection (ET) …

Memory persistence is a fundamental cognitive process for guiding behaviors and is
considered to rely mostly on neuronal and synaptic plasticity. Whether and how astrocytes …

How does the brain guide our actions? This is a complex issue, where the medial prefrontal
cortex (mPFC) plays a crucial role. The mPFC is essential for cognitive flexibility and …

Cholinergic basal forebrain (CBF) signaling exhibits multiple timescales of activity with
classic slow signals related to brain and behavioral states and fast, phasic signals reflecting …

The basolateral amygdala (BLA) is critical for associating initially neutral cues with appetitive
and aversive stimuli and receives dense neuromodulatory acetylcholine (ACh) projections …

Basal forebrain cholinergic neurons (BFCNs) modulate synaptic plasticity, cortical
processing, brain states and oscillations. However, whether distinct types of BFCNs support …

Episodic memory requires linking events in time, a function dependent on the hippocampus.
In" trace" fear conditioning, animals learn to associate a neutral cue with an aversive …