Chemical modifications in RNAs play crucial roles in diversifying their structures and
regulating numerous biochemical processes. Since the 1990s, several hydrophobic prenyl …

Abstract N6-methyladenosine (m 6 A) is the most prevalent RNA methylation modification,
and its dysregulation causes aberrant transcription and translation, which plays critical roles …

In recent years, modified nucleotides have attracted widespread attention in the field of
chemical biology, biochemistry and beyond. Although some achievements have been made …

Over the past decade, advancements in epitranscriptomics have significantly enhanced our
understanding of mRNA metabolism and its role in human development and diseases. This …

We report the use of trimethylsilyl azide and Selectfluor to implement a standard protocol
targeted at the prenylated nucleic acid known as i 6 A-RNA. After optimizing the conditions …

The persistent airway inflammation is the main characteristic of chronic obstructive
pulmonary disease (COPD), typically caused by an indoor environment pollution cigarette …

Pseudouridine (Ψ) is an abundant RNA chemical modification that plays critical biological
functions. Current Ψ detection methods are limited in identifying Ψs at base-resolution in U …

We found that the N6 methyl group of N6-methyladenine is able to hinder the methylation of
N6-methyladenine at the N1 position by DMS. Based on this, we have devised a novel …

Immunotoxicogenomics is the holistic approach to study the effect of foreign substances on
the immune system. It involves the combination of proteins and metabolites with typical …

RNA molecules undergo dynamic chemical modifications in response to various external or
cellular stimuli. Some of those modifications have been demonstrated to post …