The prefrontal cortex (PFC) has emerged as one of the regions most consistently impaired in
major depressive disorder (MDD). Although functional and structural PFC abnormalities …

During evolution, the cerebral cortex advances by increasing in surface and the introduction
of new cytoarchitectonic areas among which the prefrontal cortex (PFC) is considered to be …

Anxiety is experienced in response to threats that are distal or uncertain, involving changes
in one's subjective state, autonomic responses, and behavior. Defensive and physiologic …

The past decade has witnessed exponentially growing interest in the lateral habenula (LHb)
owing to new discoveries relating to its critical role in regulating negatively motivated …

The prefrontal cortex (PFC) orchestrates higher brain function and becomes disrupted in
many mental health disorders. The rodent medial PFC (mPFC) possesses an enormous …

Hallucinations limit widespread therapeutic use of psychedelics as rapidly acting
antidepressants. Here we profiled the non-hallucinogenic lysergic acid diethylamide (LSD) …

INTRODUCTION Depression is an episodic form of mental illness, yet the circuit-level
mechanisms driving the induction, remission, and recurrence of depressive episodes over …

Our understanding of depression and its treatment has advanced with the advent of
ketamine as a rapid-acting antidepressant and the development and refinement of tools …

Psychedelics have inspired new hope for treating brain disorders, as they seem to be unlike
any treatments currently available. Not only do they produce sustained therapeutic effects …

Over the past 10 years, the development and convergence of microbial opsin engineering,
modular genetic methods for cell-type targeting and optical strategies for guiding light …