Microbes, immunity, and behavior: psychoneuroimmunology meets the microbiome

TG Dinan, JF Cryan - Neuropsychopharmacology, 2017 - nature.com
There is now a large volume of evidence to support the view that the immune system is a key
communication pathway between the gut and brain, which plays an important role in stress …

Implications of the gut microbiome in Parkinson's disease

M Elfil, S Kamel, M Kandil, BB Koo… - Movement …, 2020 - Wiley Online Library
Parkinson's disease is a common neurodegenerative disorder that presents with nonmotor
and motor symptoms. The nonmotor manifestations of Parkinson's disease often begin years …

Microbiota-gut-brain signalling in Parkinson's disease: Implications for non-motor symptoms

VD Felice, EM Quigley, AM Sullivan… - Parkinsonism & related …, 2016 - Elsevier
Parkinson's disease is the second most common neurodegenerative disorder, affecting 1–
2% of the population over 65 years of age. The primary neuropathology is the loss of …

Vagus nerve and stomach synucleinopathy in Parkinson's disease, incidental Lewy body disease, and normal elderly subjects: evidence against the “body-first” …

TG Beach, CH Adler, LI Sue, HA Shill… - Journal of …, 2021 - content.iospress.com
Background: Braak and others have proposed that Lewy-type α-synucleinopathy in
Parkinson's disease (PD) may arise from an exogenous pathogen that passes across the …

Meta‐analysis: Association of Helicobacter pylori infection with Parkinson's diseases

X Shen, H Yang, Y Wu, D Zhang, H Jiang - Helicobacter, 2017 - Wiley Online Library
Background The results from observational studies on the relationship between helicobacter
pylori (H. pylori) infection and Parkinson's disease remain controversial. A meta‐analysis …

α-Synuclein Strains and Their Relevance to Parkinson's Disease, Multiple System Atrophy, and Dementia with Lewy Bodies

NJ Graves, Y Gambin, E Sierecki - International Journal of Molecular …, 2023 - mdpi.com
Like many neurodegenerative diseases, Parkinson's disease (PD) is characterized by the
formation of proteinaceous aggregates in brain cells. In PD, those proteinaceous aggregates …

Alpha-synuclein to the rescue: immune cell recruitment by alpha-synuclein during gastrointestinal infection

V Labrie, P Brundin - Journal of innate immunity, 2017 - karger.com
Intraneuronal accumulation of misfolded alpha-synuclein in the central and peripheral
nervous systems is strongly linked to Parkinson disease (PD) and other related …

The transcellular propagation and intracellular trafficking of α-synuclein

GK Tofaris, M Goedert… - Cold Spring …, 2017 - perspectivesinmedicine.cshlp.org
Parkinson's disease is the second most common neurodegenerative disorder, with only
partial symptomatic therapy and no mechanism-based therapies. The accumulation and …

Modelling idiopathic Parkinson disease as a complex illness can inform incidence rate in healthy adults: the PREDIGT score

MG Schlossmacher, JJ Tomlinson… - European Journal of …, 2017 - Wiley Online Library
Fifty‐five years after the concept of dopamine replacement therapy was introduced,
Parkinson disease (PD) remains an incurable neurological disorder. To date, no disease …

[HTML][HTML] The cross-sectional area of the vagus nerve is not reduced in Parkinson's disease patients

LCJ Sijben, WH Mess, U Walter, AML Janssen… - Eneurologicalsci, 2022 - Elsevier
Background Recent studies have revealed the importance of the gut brain axis in the
development of Parkinson's disease (PD). It has also been suggested that the cross …