Arrhythmias are common and contribute substantially to cardiovascular morbidity and
mortality. The underlying pathophysiology of arrhythmias is complex and remains …

Cardiac arrhythmias are a major cause of morbidity and mortality worldwide. Although
recent advances in cell-based models, including human-induced pluripotent stem cell …

E-cigarette use has surged, but the long-term health effects remain unknown. E-cigarette
aerosols containing nicotine and acrolein, a combustion and e-cigarette byproduct, may …

MicroRNAs (miRNAs) are a class of small noncoding RNAs that have gained status as
important regulators of gene expression. Here, we investigated the function and molecular …

Heart failure remains a major public health concern with a 5-year mortality rate higher than
that of most cancers. Myocardial disease in heart failure is frequently accompanied by …

Abstract Plakophilin-2 (PKP2) is a component of the desmosome and known for its role in
cell–cell adhesion. Mutations in human PKP2 associate with a life-threatening …

Sudden cardiac death exhibits diurnal variation in both acquired and hereditary forms of
heart disease,, but the molecular basis of this variation is unknown. A common mechanism …

Arrhythmias, a common cause of sudden cardiac death, can occur in structurally normal
hearts, although the mechanism is not known. In cardiac muscle, the ryanodine receptor …

In heart failure (HF), Ca 2+/calmodulin kinase II (CaMKII) expression is increased. Altered
Na+ channel gating is linked to and may promote ventricular tachyarrhythmias (VTs) in HF …

Background Empagliflozin is a selective sodium–glucose cotransporter 2 (SGLT2) inhibitor
used to lower blood sugar in adults with type 2 diabetes. Empagliflozin also exerts …