Inflammatory processes are primary contributors to the development and progression of
alcoholic steatohepatitis (ASH), with severe alcoholic hepatitis characterised by non …

Hepatic lipid metabolism is a series of complex processes that control influx and efflux of not
only hepatic lipid pools, but also organismal pools. Lipid homeostasis is usually tightly …

Alcoholism is a widespread and damaging behaviour of people throughout the world. Long-
term alcohol consumption has resulted in alcoholic liver disease (ALD) being the leading …

There are numerous prescription drugs and non-prescription drugs that cause drug-induced
liver injury (DILI), which is the main cause of liver disease in humans around the globe. Its …

Aging is a modifiable risk factor for most chronic diseases and an inevitable process in
humans. The development of pharmacological interventions aimed at delaying or preventing …

Background & Aims Liver sinusoidal endothelial cell (LSEC) dysfunction has been reported
in alcohol-related liver disease, yet it is not known whether LSECs metabolize alcohol. Thus …

A salient feature of alcoholic liver disease (ALD) is Kupffer cell (KC) activation and
recruitment of inflammatory monocytes and macrophages (MØs). These key cellular events …

Damage-associated molecular patterns are signalling molecules involved in inflammatory
responses and restoration of homeostasis. Chronic release of these molecules can also …

Alcoholic liver disease (ALD), a leading cause of chronic liver injury worldwide, comprises a
range of disorders including simple steatosis, steatohepatitis, cirrhosis, and hepatocellular …

Alcoholic fatty liver disease (AFLD) is one of the most prevalent forms of liver disease
worldwide and can progress to inflammation (hepatitis), fibrosis/cirrhosis, and ultimately lead …