Shedding light on the cell biology of extracellular vesicles

G Van Niel, G d'Angelo, G Raposo - Nature reviews Molecular cell …, 2018 - nature.com
Extracellular vesicles are a heterogeneous group of cell-derived membranous structures
comprising exosomes and microvesicles, which originate from the endosomal system or …

Disseminated intravascular coagulation

S Gando, M Levi, CH Toh - Nature reviews Disease primers, 2016 - nature.com
Disseminated intravascular coagulation (DIC) is an acquired syndrome characterized by
widespread intravascular activation of coagulation that can be caused by infectious insults …

A comparison of cellular uptake mechanisms, delivery efficacy, and intracellular fate between liposomes and extracellular vesicles

TB Gandek, L van der Koog… - Advanced healthcare …, 2023 - Wiley Online Library
A key aspect for successful drug delivery via lipid‐based nanoparticles is their
internalization in target cells. Two prominent examples of such drug delivery systems are …

Exosomes and microvesicles in normal physiology, pathophysiology, and renal diseases

A Ståhl, K Johansson, M Mossberg, R Kahn… - Pediatric …, 2019 - Springer
Extracellular vesicles are cell-derived membrane particles ranging from 30 to 5,000 nm in
size, including exosomes, microvesicles, and apoptotic bodies. They are released under …

Biological properties of extracellular vesicles and their physiological functions

M Yáñez-Mó, PRM Siljander, Z Andreu… - Journal of …, 2015 - Taylor & Francis
In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of
intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity …

Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles

M Colombo, G Raposo, C Théry - Annual review of cell and …, 2014 - annualreviews.org
In the 1980s, exosomes were described as vesicles of endosomal origin secreted from
reticulocytes. Interest increased around these extracellular vesicles, as they appeared to …

Extracellular vesicles as circulating cancer biomarkers: opportunities and challenges

RE Lane, D Korbie, MM Hill, M Trau - Clinical and translational medicine, 2018 - Springer
Extracellular vesicles (EVs) are small, lipid-bound particles containing nucleic acid and
protein cargo which are excreted from cells under a variety of normal and pathological …

Disseminated intravascular coagulation: an update on pathogenesis, diagnosis, and therapeutic strategies

C Papageorgiou, G Jourdi, E Adjambri… - Clinical and applied …, 2018 - journals.sagepub.com
Disseminated intravascular coagulation (DIC) is an acquired clinicobiological syndrome
characterized by widespread activation of coagulation leading to fibrin deposition in the …

Endothelial barrier dysfunction in septic shock

SM Opal, T Van Der Poll - Journal of internal medicine, 2015 - Wiley Online Library
The endothelium provides an essential and selective membrane barrier that regulates the
movement of water, solutes, gases, macromolecules and the cellular elements of the blood …

Microparticles in hemostasis and thrombosis

AP Owens III, N Mackman - Circulation research, 2011 - Am Heart Assoc
Blood contains microparticles (MPs) derived from a variety of cell types, including platelets,
monocytes, and endothelial cells. In addition, tumors release MPs into the circulation. MPs …