Classic psychedelics, such as LSD, psilocybin, and the DMT-containing beverage
ayahuasca, show some potential to treat depression, anxiety, and addiction. Importantly …

This paper provides a critical review of several possible mechanisms at different levels of
analysis underlying the effects and therapeutic potential of psychedelics. At the (1) …

Background Psilocybin has been suggested as a novel, rapid-acting treatment for
depression. Two consecutive doses have been shown to markedly decrease symptom …

Background This study aimed to investigate the efficacy and safety of lysergic acid
diethylamide (LSD)–assisted therapy in patients who experienced anxiety with or without …

Mescaline, lysergic acid diethylamide (LSD), and psilocybin are classic serotonergic
psychedelics. A valid, direct comparison of the effects of these substances is lacking. The …

Psilocybin is being investigated as a treatment in adults with treatment-resistant depression
(TRD). Withdrawal from serotonergic antidepressant drugs is a common prerequisite for …

Abstract N, N-dimethyltryptamine (DMT) is distinct among classic serotonergic psychedelics
because of its short-lasting effects when administered intravenously. Despite growing …

Psychedelic drugs have reemerged as tools to treat several brain disorders. Cultural
attitudes toward them are changing, and scientists are once again investigating the neural …

Background Psychedelic-assisted therapy [eg, with lysergic acid diethylamide (LSD)] has
shown promising results as treatment for substance use disorders (SUDs). Previous …

Background Lysergic acid diethylamide (LSD) is currently being investigated in psychedelic-
assisted therapy. LSD has a long duration of acute action of 8–11 hours. It produces its …