The war on multidrug resistance (MDR) has resulted in the greatest loss to the world's
economy. Antibiotics, the bedrock, and wonder drug of the 20th century have played a …

Infection is the second leading cause of death in patients with cancer. Loss of efficacy in
antibiotics due to antibiotic resistance in bacteria is an urgent threat against the continuing …

Background New antibiotics are needed for the treatment of patients with life-threatening
carbapenem-resistant Gram-negative infections. We assessed the efficacy and safety of …

ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella
pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter …

ABSTRACT The World Health Organization (WHO) has warned that our current arsenal of
antibiotics is not innovative enough to face impending infectious diseases, especially those …

Background. Infections caused by antibiotic-resistant bacteria, including carbapenem-
resistant Enterobacteriaceae, have increased in frequency, resulting in significant patient …

The increasing number of bacterial infections globally that do not respond to any available
antibiotics indicates a need to invest in—and ensure access to—new antibiotics, vaccines …

Herein, a series of novel hybrid sulfaguanidine moieties, bearing 2-cyanoacrylamide 2a–d,
pyridine-2-one 3–10, and 2-imino-2 H-chromene-3-carboxamide 11, 12 derivatives, were …

The emergence of multidrug-resistant (MDR) Pseudomonas aeruginosa, coupled with
shrinking antibiotic pipelines, has increased the demand for new antimicrobials with novel …

Highlights•Use of Monte Carlo simulation to support antibacterial dose selection.•Inputs for
PK-PD target attainment analyses to support antibacterial dose selection.•Discussion of …