The review highlights the hydantoin syntheses presented from the point of view of the
preparation methods. Novel synthetic routes to various hydantoin structures, the advances …

Hydantoins and their hybrids with other molecules represent a very important group of
heterocycles because they exhibit diverse biological and pharmacological activities in …

The development of new strategies for the synthesis of small-sized heterocycles has
remained a highly attractive but challenging proposition. An overview of the application of …

This compendium focuses on functionalised sugar amino acids (SAAs) and their 3-to 6-
membered nitrogen heterocyclic and carbocyclic analogues. The main benefit of using SAAs …

The quantitative assessment of intermolecular interactions and their cooperative effects has
been performed in spirohydantoin-based model compounds, 3-benzoyl-1, 3-diazaspiro [4.5] …

Fragment-based drug design has been successfully applied to a large set of proteins,
however in order to expand this concept to the most demanding targets, such as protein …

Background: Microwave irradiation has emerged as a useful synthetic strategy for chemists
and drug developers due to enhanced yields, regioselectivity, and faster reaction times. One …

Cancer is a serious health problem due to the complexity of establishing an effective
treatment. The purpose of this work was to evaluate the activity of a triazaspirane as a …

The microwave-assisted synthesis of β-cyanoketones from chalcones under Bucherer–
Bergs reaction conditions was described. The structure of the synthesized compounds was …

Two spirohydantoin derivatives, 3-(4-chlorobenzoyl)-1, 3-diazaspiro [4.5] decane-2, 4-dione
(1) and 3-(4-bromobenzoyl)-1, 3-diazaspiro [4.5] decane-2, 4-dione (2), were synthesized …