The immune system and cancer have a complex relationship with the immune system
playing a dual role in tumor development. The effector cells of the immune system can …

Dendritic-cells (DCs) have received considerable attention as potential targets for the
development of anticancer vaccines. DC-based anticancer vaccination relies on patient …

T cells that recognize tumor antigens are crucial for mounting antitumor immune responses.
Induction of antitumor T cells in immunogenic tumors depends on STING, the intracellular …

In addition to helper and regulatory potential, CD4+ T cells also acquire cytotoxic activity
marked by granzyme B (GzmB) expression and the ability to promote rejection of …

Although adoptive T cell therapy provides the T cell pool needed for immediate tumor
debulking, the infused T cells generally have a narrow repertoire for antigen recognition and …

Myeloid immune cells (MICs) are potent innate immune cells serving as first responders to
invading pathogens and internal changes to cellular homeostasis. Cancer is a stage of …

Among all tumor types, skin cancers are profoundly sensitive to immunotherapy. Indeed, the
recently reported response rates for anti-PD-1 (anti-programmed-death 1) therapy for …

FLT3-L-dependent classical dendritic cells (cDCs) recruit anti-tumor and tumor-protecting
lymphocytes. We evaluate cancer growth in mice with low, normal, or high levels of cDCs …

Chimeric antigen receptor (CAR) T cells provide a promising approach to the treatment of
hematologic malignancies and solid tumors. Flow cytometry is a powerful analytical …

Advances in academic and clinical studies during the last several years have resulted in
practical outcomes in adoptive immune therapy of cancer. Immune cells can be programmed …