Inequalities in health outcomes impose substantial human and economic costs on all
societies—and the relation between early adversity and lifelong well-being presents a rich …

In the past two decades, much evidence has accumulated unequivocally demonstrating that
child abuse and neglect is associated with a marked increase in risk for major psychiatric …

Objectives: To provide advice and guidance regarding the management of mood disorders,
derived from scientific evidence and supplemented by expert clinical consensus to formulate …

Background Many depressed patients are not able to achieve or sustain symptom remission
despite serial treatment trials–often termed “treatment resistant depression”. A broader …

A plethora of research has implicated hundreds of putative biomarkers for depression, but
has not yet fully elucidated their roles in depressive illness or established what is abnormal …

Major depressive disorder is a leading cause of disability worldwide. Because conventional
therapies are ineffective in many patients, novel strategies are needed to overcome …

During the last decades, schizophrenia has been regarded as a developmental disorder.
The neurodevelopmental hypothesis proposes schizophrenia to be related to genetic and …

The experience of childhood trauma (CT) and stressful life events (SLEs) is associated with
subsequent development of a variety of mental health conditions, including psychotic illness …

Background: Depressive disorder is one of the main health problems worldwide. Many risk
factors have been associated with this pathology. However, while the association between …

Background This study tests whether depression, psychosocial adversity, and limited social
assets offer protection or suggest vulnerability to the process of radicalisation. Methods A …