The blood–brain barrier (BBB) prevents efficient drug delivery to the central nervous system.
As a result, brain diseases remain one of the greatest unmet medical needs. Understanding …

Translation of novel therapies for brain cancer into clinical practice is of the utmost
importance as primary brain tumors are responsible for more than 200,000 deaths …

Due to their biocompatibility, non-toxicity, and surface-conjugation capabilities, liposomes
are effective nanocarriers that can encapsulate chemotherapeutic drugs and facilitate …

The blood–brain barrier (BBB) is a sophisticated structure whose full functionality is required
for maintaining the executive functions of the central nervous system (CNS). Tight control of …

Cell therapy is one of the methods that have shown promising results in treating diseases in
recent decades. However, the use of different types of cells comes with limitations. The …

The FDA has predicted that at least 10-20 gene therapy products will be approved by 2025.
The surge in the development of such therapies can be attributed to the advent of safe and …

Proteins are essential for life, as they participate in all vital processes in the body. In the past
decade, delivery of active proteins to specific cells and organs has attracted increasing …

As an ideal in vitro model, brain‐on‐chip (BoC) is an important tool to comprehensively
elucidate brain characteristics. However, the in vitro model for the definition scope of BoC …

In the last few decades, adverse reactions to pharmaceuticals have been evaluated using
2D in vitro models and animal models. However, with increasing computational power, and …

One of the greatest challenges with successful pharmaceutical treatments of central nervous
system (CNS) diseases is the delivery of drugs into their target sites with appropriate …