Interactions between the immune and nervous systems are of central importance in
neuropathic pain, a common and debilitating form of chronic pain caused by a lesion or …

It is generally believed that immune activation can elicit pain through production of
inflammatory mediators that can activate nociceptive sensory neurons. Emerging evidence …

Vulvodynia is a debilitating condition characterized by painful sensitivity to touch and
pressure in the vestibular tissue surrounding the vaginal opening. It is often a “diagnosis of …

Physiological pain serves as a warning of exposure to danger and prompts us to withdraw
from noxious stimuli to prevent tissue damage. Pain can also alert us of an infection or organ …

Fibromyalgia (FM) remains a condition with a pathogenesis that is not completely
understood, affecting a significant portion of the global population. This article summarises …

Abstract An estimated 10%–50% of patients undergoing a surgical intervention will develop
persistent postsurgical pain (PPP) lasting more than 3 months despite adequate acute pain …

Circulating monocytes participate in pain chronification but the molecular events that cause
their deployment are unclear. Using a mouse model of hyperalgesic priming (HP), we show …

The introduction of sex-as-a-biological-variable policies at funding agencies around the
world has led to an explosion of very recent observations of sex differences in the biology …

Abstract Non-neuronal cells constitute 90%–95% of sensory ganglia. These cells, especially
glial and immune cells, play critical roles in the modulation of sensory neurons. This study …

Pain is estimated to affect more than 20% of the global population, imposing incalculable
health and economic burdens. Effective pain management is crucial for individuals suffering …