Cytoplasmic dynein 1 is an important microtubule-based motor in many eukaryotic cells.
Dynein has critical roles both in interphase and during cell division. Here, we focus on …

The folding of transmembrane proteins into the outer membrane presents formidable
challenges to Gram-negative bacteria. These proteins must migrate from the cytoplasm …

Cytoplasmic dynein is a microtubule motor that is activated by its cofactor dynactin and a
coiled-coil cargo adaptor,–. Up to two dynein dimers can be recruited per dynactin, and …

Dynein and its cofactor dynactin form a highly processive microtubule motor in the presence
of an activating adaptor, such as BICD2. Different adaptors link dynein and dynactin to …

Cytoplasmic dynein-1 binds dynactin and cargo adaptor proteins to form a transport
machine capable of long-distance processive movement along microtubules. However, it is …

Dynactin is an essential cofactor for the microtubule motor cytoplasmic dynein-1. We report
the structure of the 23-subunit dynactin complex by cryo-electron microscopy to 4.0 …

Cytoplasmic dynein is a microtubule motor vital for cellular organization and division. It
functions as a~ 4-megadalton complex containing its cofactor dynactin and a cargo-specific …

Dynein-2 assembles with polymeric intraflagellar transport (IFT) trains to form a transport
machinery that is crucial for cilia biogenesis and signaling. Here we recombinantly …

Thousands of outer-arm dyneins (OADs) are arrayed in the axoneme to drive a rhythmic
ciliary beat. Coordination among multiple OADs is essential for generating mechanical …

It is now clear that transport on microtubules by dynein and kinesin family motors has an
important if not critical role in the replication and spread of many different viruses …