On the basis of our own experimental data and analysis of data from the literature the
existence of nitric oxide cycle in mammals is substantiated. Two components underlie the …

Glyceryl trinitrate, isosorbide dinitrate, and isosorbide-5-mononitrate are organic nitrate
esters commonly used in the treatment of angina pectoris, myocardial infarction, and …

Peroxynitrite [oxoperoxonitrate (l-), ONOO-] may be formed in vivo from superoxide and nitric
oxide. The anion is stable, but the acid (pK&= 6.8) decays to nitrate with a rate of 1.3 s" 1 at …

We have performed density functional theory (DFT) calculations of iron− porphyrin (FeP) and
its complexes with O2, CO, NO, and imidazole (Im). Our fully optimized structures agree well …

An active preparation of the membrane-associated methane monooxygenase (pMMO) from
Methylococcus capsulatus Bath was isolated by ion-exchange and hydrophobic interaction …

Homocysteine is a key junction metabolite that can be converted to cystathionine in a
reaction catalyzed by the heme and pyridoxal phosphate-dependent cystathionine β …

The mechanism of activation of soluble guanylate cyclase purified from bovine lung by high
molecular weight, nitrosyl-hemoprotein complexes is reported. Heme-containing, heme …

Soluble guanylate cyclase [GTP pyrophosphate-lyase (cyclizing), EC 4.6. 1.2] purified from
bovine lung is markedly activated (30-to 40-fold) by protoporphyrin IX (Ka, 15-25 nM) and is …

Ferrihemoproteins in buffer solutions bind nitric oxide to yield their nitric oxide adducts.
Reversible binding of NO was found for ferricytochrome c (CytIII) and metmyoglobin (MbIII) …

The nitrosation of cellular thiols has attracted much interest as a regulatory mechanism that
mediates some of the pathophysiological effects of nitric oxide (NO). In cells, virtually all …