Protein lysine acetylation is an important posttranslational modification that regulates
numerous biological processes. Targeting lysine acetylation regulatory factors, such as …

Cell cycle and apoptosis regulator 2 (CCAR2), also known as deleted in breast cancer 1
(DBC1), has been recently identified as a master regulator of transcriptional processes and …

DBC1 has been characterized as a key regulator of physiological and pathophysiological
activities, such as DNA damage, senescence, and tumorigenesis. However, the mechanism …

Hundreds of DNA repair proteins coordinate together to remove the diverse damages for
ensuring the genomic integrity and stability. The repair system is an extensive network …

CCAR2 (cell cycle and apoptosis regulator 2) controls a variety of cellular functions;
however, its main function is to regulate cell survival and cell death in response to genotoxic …

Abstract Cell Cycle and Apoptosis Regulator 1 (CCAR1) and Cell Cycle and Apoptosis
Regulator 2 (CCAR2) have emerged as key players in physiology and pathophysiology, with …

Epithelial-mesenchymal transition (EMT) is a key process in tumor metastatic cascade that is
characterized by the loss of cell-cell junctions, resulting in the acquisition of migratory and …

Lysine acetylation has recently emerged as an important post-translational modification in
diverse organisms, but relatively little is known about its roles in mammalian development …

There continues to be interest in targeting epigenetic “readers, writers, and erasers” for the
treatment of cancer and other pathologies. However, a mechanistic understanding is …

Abstract Human DBC1 (Deleted in Breast Cancer 1; KIAA1967; CCAR2) is a protein
implicated in the regulation of apoptosis, transcription and histone modifications. Upon DNA …