Roles and regulation of tRNA-derived small RNAs in animals

S Muthukumar, CT Li, RJ Liu, C Bellodi - Nature Reviews Molecular Cell …, 2024 - nature.com
A growing class of small RNAs, known as tRNA-derived RNAs (tdRs), tRNA-derived small
RNAs or tRNA-derived fragments, have long been considered mere intermediates of tRNA …

Emerging functions for snoRNAs and snoRNA-derived fragments

M Wajahat, CP Bracken, A Orang - International journal of molecular …, 2021 - mdpi.com
The widespread implementation of mass sequencing has revealed a diverse landscape of
small RNAs derived from larger precursors. Whilst many of these are likely to be byproducts …

Extracellular vesicles as next generation immunotherapeutics

DW Greening, R Xu, A Ale, CE Hagemeyer… - Seminars in Cancer …, 2023 - Elsevier
Extracellular vesicles (EVs) function as a mode of intercellular communication and
molecular transfer to elicit diverse biological/functional response. Accumulating evidence …

[HTML][HTML] The role of RNA m5C modification in cancer metastasis

Q Zhang, F Liu, W Chen, H Miao, H Liang… - … journal of biological …, 2021 - ncbi.nlm.nih.gov
Epigenetic modification plays a crucial regulatory role in the biological processes of
eukaryotic cells. The recent characterization of DNA and RNA methylation is still ongoing …

A novel 3'tRNA-derived fragment tRF-Val promotes proliferation and inhibits apoptosis by targeting EEF1A1 in gastric cancer

H Cui, H Li, H Wu, F Du, X Xie, S Zeng, Z Zhang… - Cell Death & …, 2022 - nature.com
At present, it is commonly believed that tRFs and tiRNAs are formed by the specific and
selective shear of tRNAs under certain pressure stimulation, rather than by random …

The role of noncoding RNAs in Parkinson's disease: biomarkers and associations with pathogenic pathways

MC Kuo, SCH Liu, YF Hsu, RM Wu - Journal of biomedical science, 2021 - Springer
The discovery of various noncoding RNAs (ncRNAs) and their biological implications is a
growing area in cell biology. Increasing evidence has revealed canonical and noncanonical …

A novel tyrosine tRNA-derived fragment, tRFTyr, induces oncogenesis and lactate accumulation in LSCC by interacting with LDHA

R Zhao, Z Yang, B Zhao, W Li, Y Liu, X Chen… - Cellular & Molecular …, 2023 - Springer
Background Transfer (t) RNA-derived small RNA (tsRNA), generated from precursor or
mature tRNA, is a new type of small non-coding RNA (sncRNA) that has recently been …

Non-coding RNAs targeting notch signaling pathway in cancer: From proliferation to cancer therapy resistance

M Hashemi, S Hasani, S Hajimazdarany… - International journal of …, 2022 - Elsevier
Cancer is a challenging to treat disease with a high mortality rate worldwide, nevertheless
advances in science has led to a decrease in the number of death cases caused by cancer …

tRNAGlyGCC-Derived Internal Fragment (i-tRF-GlyGCC) in Ovarian Cancer Treatment Outcome and Progression

K Panoutsopoulou, T Dreyer, J Dorn, E Obermayr… - Cancers, 2021 - mdpi.com
Simple Summary In the precision medicine era, epithelial ovarian cancer (EOC) is
characterized by a high death-to-incidence rate and poor 5-year survival. The identification …

Alveolar macrophage-derived exosomal tRF-22-8BWS7K092 activates Hippo signaling pathway to induce ferroptosis in acute lung injury

W Wang, L Zhu, H Li, W Ren, R Zhuo, C Feng… - International …, 2022 - Elsevier
Abstract Background Alveolar macrophages (AMs) play a demonstrative role in acute lung
injury (ALI). Exosomes act as signaling molecules to regulate cell-to-cell communication by …