The major concern for anticancer chemotherapeutic agents is the host toxicity. The
development of anticancer prodrugs targeting the unique biochemical alterations in cancer …

The following review analyzes the most effective activation protocols for the generation of
transient electrophilic quinone methides, merged into the recent strategies to achieve …

Irradiation of 3-hydroxy-2-naphthalenemethanol (3a) and 2-hydroxy-1-
naphthalenemethanol (4a) results in efficient (Φ254= 0.17 and 0.20) dehydration and the …

A one-step protecting-group-free synthesis of both 6-hydroxy-naphthalene-2-carbaldehyde
and the bifunctional binaphthalenyl derivative afforded 6-hydroxymethylnaphthalen-2-ol, 6 …

Existence of G-quadruplex DNA in vivo always attract widespread interest in the field of
biology and biological chemistry. We reported our findings for the existence of G-quadruplex …

DNA interstrand crosslinks (ICLs) can be induced by numerous endogenous and
exogenous chemical agents with the capacity of covalently binding to two base sites in the …

Neuroinflammation, in particular activation of microglia, is thought to play an important role
in the progression of neurodegenerative diseases. In activated microglia, the purinergic …

It has been 20 years since the publication of Chemistry of Protein Conjugation and Cross-
Linking. During this period, great advances have been made in the area of cross-linking of …

We describe several new aromatic nitrogen mustards with various aromatic substituents and
boronic esters that can be activated with H2O2 to efficiently cross-link DNA. In vitro studies …

Some antitumor drugs react with DNA by inducing DNA interstrand cross-links (ICLs) which
can block DNA transcription and replication.[1] ICL-inducing agents, such as nitrogen …