To PEGylate or not to PEGylate: Immunological properties of nanomedicine's most popular component, polyethylene glycol and its alternatives
Polyethylene glycol or PEG has a long history of use in medicine. Many conventional
formulations utilize PEG as either an active ingredient or an excipient. PEG found its use in …
formulations utilize PEG as either an active ingredient or an excipient. PEG found its use in …
Multifunctional biomolecule nanostructures for cancer therapy
J Wang, Y Li, G Nie - Nature Reviews Materials, 2021 - nature.com
Biomolecule-based nanostructures are inherently multifunctional and harbour diverse
biological activities, which can be explored for cancer nanomedicine. The supramolecular …
biological activities, which can be explored for cancer nanomedicine. The supramolecular …
Mesoporous silica nanoparticles: Facile surface functionalization and versatile biomedical applications in oncology
R Huang, YW Shen, YY Guan, YX Jiang, Y Wu… - Acta Biomaterialia, 2020 - Elsevier
Mesoporous silica nanoparticles (MSNs) have received increasing interest due to their
tunable particle size, large surface area, stable framework, and easy surface modification …
tunable particle size, large surface area, stable framework, and easy surface modification …
Exosomes as natural delivery carriers for programmable therapeutic nucleic acid nanoparticles (NANPs)
W Ke, KA Afonin - Advanced drug delivery reviews, 2021 - Elsevier
With recent advances in nanotechnology and therapeutic nucleic acids (TNAs), various
nucleic acid nanoparticles (NANPs) have demonstrated great promise in diagnostics and …
nucleic acid nanoparticles (NANPs) have demonstrated great promise in diagnostics and …
Aptamers as modular components of therapeutic nucleic acid nanotechnology
M Panigaj, MB Johnson, W Ke, J McMillan… - Therapeutic RNA …, 2021 - taylorfrancis.com
Nucleic acids play a central role in all domains of life, either as genetic blueprints or as
regulators of various biochemical pathways. The 826chemical makeup of ribonucleic acid …
regulators of various biochemical pathways. The 826chemical makeup of ribonucleic acid …
Critical review of nucleic acid nanotechnology to identify gaps and inform a strategy for accelerated clinical translation
KA Afonin, MA Dobrovolskaia, W Ke… - Advanced drug delivery …, 2022 - Elsevier
With numerous recent advances, the field of therapeutic nucleic acid nanotechnology is now
poised for clinical translation supported by several examples of FDA-approved nucleic acid …
poised for clinical translation supported by several examples of FDA-approved nucleic acid …
Nanofibers for the immunoregulation in biomedical applications
L Fu, Q Feng, Y Chen, J Fu, X Zhou, C He - Advanced Fiber Materials, 2022 - Springer
Despite great efforts and achievement of nanomaterials in immune-associated diseases, the
selection of appropriate nanomaterials and preparation technology remain some challenges …
selection of appropriate nanomaterials and preparation technology remain some challenges …
Pro‐peptide‐reinforced, mucus‐penetrating pulmonary siRNA delivery mitigates cytokine storm in pneumonia
J Yang, S Duan, H Ye, C Ge, C Piao… - Advanced Functional …, 2021 - Wiley Online Library
Pulmonary delivery of anti‐inflammatory siRNA holds great potential in mitigating the
cytokine storm during severe pneumonia. However, commonly utilized polycationic siRNA …
cytokine storm during severe pneumonia. However, commonly utilized polycationic siRNA …
RNA–DNA fibers and polygons with controlled immunorecognition activate RNAi, FRET and transcriptional regulation of NF-κB in human cells
W Ke, E Hong, RF Saito, MC Rangel… - Nucleic acids …, 2019 - academic.oup.com
Nucleic acid–based assemblies that interact with each other and further communicate with
the cellular machinery in a controlled manner represent a new class of reconfigurable …
the cellular machinery in a controlled manner represent a new class of reconfigurable …
Artificial Immune Cell, AI‐cell, a New Tool to Predict Interferon Production by Peripheral Blood Monocytes in Response to Nucleic Acid Nanoparticles
M Chandler, S Jain, J Halman, E Hong… - Small, 2022 - Wiley Online Library
Nucleic acid nanoparticles, or NANPs, rationally designed to communicate with the human
immune system, can offer innovative therapeutic strategies to overcome the limitations of …
immune system, can offer innovative therapeutic strategies to overcome the limitations of …