Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection. Over decades, advanced …

The glycocalyx is a gel-like layer covering the luminal surface of vascular endothelial cells. It
is comprised of membrane-attached proteoglycans, glycosaminoglycan chains …

Systemic inflammation can be triggered by infection, surgery, trauma or burns. During
systemic inflammation, an overshooting immune response induces tissue damage resulting …

Aging is a major risk factor of high incidence and increased mortality of acute respiratory
distress syndrome (ARDS). Here, we demonstrated that persistent lung injury and high …

As a result of evolutionary selection, the subunits of naturally occurring protein assemblies
often fit together with substantial shape complementarity to generate architectures optimal …

The endothelial angiopoietin (ANG)–TIE growth factor receptor pathway regulates vascular
permeability and pathological vascular remodelling during inflammation, tumour …

Angiogenesis is a multistep process that requires coordinated migration, proliferation, and
junction formation of vascular endothelial cells (ECs) to form new vessel branches in …

Sepsis accounts for nearly 700 000 deaths in Europe annually and is caused by an
overwhelming host response to infection resulting in organ failure. The endothelium is an …

The lung is highly vulnerable during sepsis, yet its functional deterioration accompanied by
disturbances in the pulmonary microcirculation is poorly understood. This study aimed to …

A destabilized tumor vasculature leads to limited drug delivery, hypoxia, detrimental tumor
microenvironment, and even metastasis. We performed a side-by-side comparison of …