Necrotizing enterocolitis (NEC) is the leading cause of death and disability from
gastrointestinal disease in premature infants. Recent discoveries have shed light on a …

Mucosal surfaces in the gastrointestinal tract are continually exposed to native, commensal
antigens and susceptible to foreign, infectious antigens. Immunoglobulin A (IgA) provides …

A key aspect of postnatal intestinal adaptation is the establishment of symbiotic relationships
with co-evolved gut microbiota. Necrotizing enterocolitis (NEC) is the most severe disease …

Necrotizing enterocolitis (NEC) is a devastating gastrointestinal disorder in premature
infants that causes significant morbidity and mortality. Research efforts into the pathogenesis …

Background The gastrointestinal (GI) microbiota has been linked to health consequences
throughout life, from early life illnesses (eg sepsis and necrotising enterocolitis) to lifelong …

Background Necrotizing enterocolitis (NEC) is the most prevalent gastrointestinal disorder
that predominantly threatens preterm newborns. Succinate is an emerging metabolic …

The development and health of infants are intertwined with the protective and regulatory
functions of different microorganisms in the gut known as the gut microbiota. Preterm infants …

Human milk is the most valuable source of nutrition for infants. The structure and function of
human milk oligosaccharides (HMOs), which are key components of human milk, have long …

The neonatal period is a critical phase for the development of the intestinal immune system,
marked by rapid adaptation to the external environment and unique nutritional demands …

Purpose Necrotizing enterocolitis (NEC) is the most severe gastrointestinal disease in
preterm infants caused by an exaggerated intestinal epithelial immune activation. Several …