Pro-opiomelanocortin (POMC) is the archetypal polypeptide precursor of hormones and
neuropeptides. In this review, we examine the variability in the individual peptides produced …

Gene regulation by steroid hormones is mediated through an interaction of the hormone
receptors with DNA regulatory sequences called hormone regulatory or responsive …

By genetically targeting tumorigenesis to specific hypothalamic neurons in transgenic mice
using the promoter region of the gonadotropin-releasing hormone (GnRH) gene to express …

Study of the molecular and cellular biology of the gonadotropin hormones would be greatly
facilitated by the availability of immortalized anterior pituitary gonadotrope cell lines. We …

Targeted expression of oncogenes in transgenic mice can immortalize specific cell types to
serve as valuable cultured model systems. Utilizing promoter regions from a set of genes …

Glucocorticoids rapidly and specifically inhibit transcription of the pro-opiomelanocortin
(POMC) gene in the anterior pituitary, thus offering a model for studying negative control of …

Two case reports published in the early 1950s described cardiovascular collapse and death
in young patients undergoing routine orthopaedic surgery. A 34-year-old man died after the …

The hypothalamo‐pituitary‐adrenal axis (HPA) is responsible for stimulation of adrenal
corticosteroids in response to stress. Negative feedback control by corticosteroids limits …

Two important functions of glucocorticoids (Gc), namely, suppression of immune system
function and feedback repression of the hypothalamo-pituitary-adrenal (HPA) axis, are …

The possible role that the hypothalamic arcuate nucleus might play in mediating the
increase in paraventricular nucleus corticotropin‐releasing hormone mRNA levels following …